降钙素原、白介素6、瓜氨酸和肠三叶因子水平对严重多发伤伴发急性胃肠损伤有预测价值  

Predictive value of procalcitonin,interleukin-6,citrulline,and intestinal trefoil factor in severe multiple injuries accompanied by acute gastrointestinal injury

作　　者：黄承 田仁富 朱顺 杨先芹 HUANG Cheng;TIAN Ren-fu;ZHU Shun;YANG Xian-qin(Intensive Care Department of Enshi Tujia and Miao Autonomous Prefecture Central Hospital,Hubei Enshi 445000,China)

机构地区：[1]恩施土家族苗族自治州中心医院重症医学科,湖北恩施445000

出　　处：《内科急危重症杂志》2024年第1期64-66,共3页Journal of Critical Care In Internal Medicine

摘　　要：目的:探讨降钙素原(PCT)、白介素(IL)-6、瓜氨酸、肠三叶因子(ITF)对多发伤患者并发急性胃肠损伤(AGI)的预测价值。方法:分析130例严重多发伤患者临床资料,按照入院72 h内是否出现AGI,分为AGI组(71例)和无AGI组(59例)。比较2组血清PCT、IL-6、瓜氨酸和ITF水平变化。采用多因素Logistic回归分析影响严重多发伤患者并发AGI的危险因素。结果:2组患者伤后第1、3、5天的PCT、IL-6、瓜氨酸及ITF水平比较,差异均有统计学差异(P均<0.05)。多因素Logistics回归分析显示,血清IL-6、瓜氨酸是影响严重多发伤患者并发AGI的独立危险因素(P均<0.05)。结论:严重多发伤并发AGI患者的血降钙素原、IL-6和ITF水平明显升高,瓜氨酸水平逐渐降低再升高,这些指标是影响AGI发生的危险因素。Objective:To explore the predictive value of procalcitonin(PCT),interleukin-6(IL-6),citrulline,and intestinal trefoil factor(ITF) in patients with multiple injuries complicated with acute gastrointestinal injury(ACI).Method:The clinical data of 130 patients with severe multiple injuries were analyzed and divided into ACI group(71 cases) and non-ACI group(59 cases) based on whether ACI occurred within 72 h of admission.The changes in serum PCT,IL-6,citrulline,and ITF levels were compared between two groups.The multiple logistic regression analysis was used to identify the risk factors for AGI in patients with severe multiple injuries.Result:There were statistically significant differences(P<0.05) in the levels of PCT,IL-6,citrulline,and ITF between the two groups on the first,third,and fifth day after injury.Multivariate logistic regression analysis showed that serum IL6 and citrulline were independent risk factors for AGI in patients with severe multiple injuries(all P<0.05).Conclusion:The levels of procalcitonin,L6,and TF in patients with severe multiple injuries complicated by ACI significantly increase,while the levels of citrulline gradually decrease and then increase.These indicators are risk factors affecting the occurrence of AGI.

关 键 词：严重多发伤 急性胃肠损伤 相关性分析 

分 类 号：R573[医药卫生—消化系统]