Single nucleotide polymorphism within chromosome 8q24 is associated with prostate cancer development in Saudi Arabia  

作　　者：Awad Elsid Osman Sahar Alharbi Atif Ali Ahmed Asim Ali Elbagir 

机构地区：[1]Pathology and Clinical Laboratory Management Department(PCLM),King Fahad Medical City,Riyadh,Saudi Arabia [2]Department of Pathology and Laboratory Medicine,University of Missouri at Children's Mercy Hospital,Kansas City,MO,USA

出　　处：《Asian Journal of Urology》2024年第1期26-32,共7页亚洲泌尿外科杂志（英文）

基　　金：supported by King Fahad Medical City,Riyadh,Saudi Arabia(IRF No:017-059).

摘　　要：Objective: Genome-wide association studies have demonstrated that single nucleotide polymorphisms (SNPs) are important risk factors for the development of prostate cancer (PCa). Preliminary studies have suggested that the incidence of PCa in Saudi males is low but is probably familial or genetically related.Methods: To identify any possible association of SNP with PCa development in Saudi patients, we investigated a group of SNPs in Saudi PCa patients (n=85) and compared the outcomes to healthy normal controls (n=115) and nodular hyperplasia patients (n=120). DNA was extracted from paraffin-embedded formalin fixed tissue or whole blood from both patients’ groups and healthy control group. A total of thirteen SNPs were genotyped using TaqMan® minor groove binder polymerase chain reaction assay.Results: The rs16901979A, s629242T and rs1447295A alleles were found at significantly higher frequency in PCa patients than controls (p< 0.05). The rs16901979 CA genotype was found at significantly greater frequency in PCa patients than in healthy controls (43% vs. 14%, odds ratio=4.6, p=0.0001) and benign hyperplasia group (43% vs. 25%, odds ratio=2.2, p=0.009).Conclusion: Our study has highlighted the association of rs16901979 SNP with PCa in Saudi males. Such findings have important implications in the PCa diagnosis and in screening unaffected family members of Saudi patients.

关 键 词：Prostatecancer SAUDI Singlenucleotide polymorphism ALLELE 

分 类 号：R737.25[医药卫生—肿瘤]