河南省农村人群糖皮质激素受体基因rs9324921和rs9324924多态性与脑卒中的关系  

Relationship between genetic polymorphisms of glucocorticoid receptor rs9324921 and rs9324924 and stroke among rural population in Henan Province

作　　者：徐克 史佳雨 马翠翠 赵梦真 耿巾甜 毛振兴 付余[2,3] XU Ke;SHI Jiayu;MA Cuicui;ZHAO Mengzhen;GENG Jintian;MAO Zhenxing;FU Yu(Department of Nursing,College of Nursing and Health,Zhengzhou University,Zhengzhou 450001;Department of Computer and Biostatistics,College of Public Health,Zhengzhou University,Zhengzhou 450001;Office of Procurement Supply Bidding,Henan Cancer Hospital,Zhengzhou 450000)

机构地区：[1]郑州大学护理与健康学院护理教研室,郑州450001 [2]郑州大学公共卫生学院计算机与卫生统计学教研室,郑州450001 [3]河南省肿瘤医院采购供应招标办公室,郑州450000

出　　处：《郑州大学学报（医学版）》2024年第2期280-283,共4页Journal of Zhengzhou University(Medical Sciences)

基　　金：国家自然科学基金项目(42177415);中国博士后科学基金项目(2020T130604);河南省高校科技创新人才支持计划项目(22HASTIT044)。

摘　　要：目的:评估河南省农村人群的糖皮质激素受体基因rs9324921和rs9324924多态性与脑卒中的关系。方法:选择来自“河南省农村队列研究”2015至2017年基线调查的255例脑卒中患者,按照同性别和年龄相差不超过3岁的原则3∶1匹配同期参与研究的对照人群(n=765)。从全血中提取DNA后采用SNPscan技术对糖皮质激素受体基因rs9324921和rs9324924进行基因分型。采用Logistic回归分析糖皮质激素受体基因rs9324921和rs9324924多态性与脑卒中的关系。结果:调整混杂因素后,糖皮质激素受体基因rs9324921位点A等位基因或AA基因型脑卒中患病风险增加,OR(95%CI)分别为1.374(1.071~1.762)或2.240(1.173~4.280)。rs9324924位点T等位基因或TT基因型脑卒中患病风险增加,OR(95%CI)分别为1.414(1.143~1.748)或2.035(1.330~3.111)。结论:河南省农村人群糖皮质激素受体基因rs9324921位点A等位基因和rs9324924位点T等位基因与脑卒中的发病风险有关。Aim:To assess the relationship of glucocorticoid receptors(GR)SNP sites rs9324921 and rs9324924 with stroke among rural population in Henan Province.Methods:A total of 255 stroke patients from the survey of"Henan Rural Cohort"from 2015 to 2017 were selected.According to gender and age difference within 3 years,the control population(n=765)participated at the same time was matched with the ratio of 3∶1.rs9324921 and rs9324924 were genotyped using SNPscan after DNA was extracted from whole blood.Logistic regression model was used to assess the correlations between GR rs9324921 and rs9324924 and stroke.Results:After adjusting for confounding factors,allele A or genotype AA at the rs9324921 locus,and allele T or genotype TT at the rs9324924 locus had a significantly higher risk of stroke,with OR(95%CI)of 1.374(1.071-1.762),2.240(1.173-4.280),1.414(1.143-1.748),2.035(1.330-3.111),respectively.Conclusion:Allele A at the rs9324921 locus and allele T at the rs9324924 locus of the GR gene are associated with higher risk of stroke among rural population in Henan Province.

关 键 词：糖皮质激素受体 脑卒中 基因多态性 河南省 

分 类 号：R394.5[医药卫生—医学遗传学]