Efficacy and safety of Chinese herbal medicine as adjunctive therapy in sepsis patients with bloodstream infection:a propensity-matched analysis  

作　　者：ZHOU Xianshi ZHONG Minlin XI Xiaotu LI Jun TANG Guanghua 

机构地区：[1]the Second Clinical College of Guangzhou University of Chinese Medicine,Guangzhou 510120,China [2]Emergency Department,Guangdong Provincial Hospital of Chinese Medicine,Guangzhou 510120,China [3]Guangdong Provincial Key Laboratory of Research on Emergency in TCM,Guangzhou 510120,China [4]Guangzhou Key Laboratory of Traditional Chinese Medicine for Prevention and Treatment of Emerging Infectious Diseases,Guangzhou 510120,China [5]Administration Department,the First Hospital of Guangzhou University of Chinese Medicine,Guangzhou 510405,China

出　　处：《Journal of Traditional Chinese Medicine》2024年第1期197-204,共8页中医杂志（英文版）

基　　金：Supported by Clinical Research Program of Guangdong Provincial Hospital of Chinese Medicine:Exploring the Epidemiological Characteristics and Screening Key Prognostic Indicators of Sepsis Patients with Bloodstream Infection(No.2019KT1317);which is a sub-project of Guangdong Provincial Key Laboratory of Research on Emergency in TCM(No.2017B030314176)。

摘　　要：OBJECTIVE:To investigate the efficacy and safety of Chinese herbal medicine in treating sepsis patients with bloodstream infection.METHODS:A 6-year retrospective study was carried out at a university hospital in China.Adult sepsis patients with bloodstream infection were included.The primary outcome was 28-day mortality after admission.Propensity score method was used to adjust for possible confounding.28-day mortality was estimated by KaplanMeier analysis and compared using the log-rank test.Cox regression analysis was carried out to identify factors impacting in-hospital mortality outcomes.RESULTS:Following the application of the propensity score method,a total of 176 patients were included.The all-cause 28-day mortality in the control group and Chinese herbal medicine group was 21.6%and 14.8%,respectively.Kaplan-Meier survival analysis showed that Chinese herbal medicine was associated with a lower hazard ratio(HR)in all-cause 28-day death compared with the control group[HR=0.44,95%CI(0.22,0.90),P<0.05].The complications were similar between the two groups(P>0.05).Blood-activating and stasis-eliminating herb administration was associated with reduced inhospital mortality among sepsis patients with bloodstream infection[HR=0.54,95%CI(0.34,0.94),P<0.05].CONCLUSIONS:Chinese herbal medicine,especially the blood-activating and stasis-eliminating herb,might have certain efficacy and safety in treating sepsis patients with bloodstream infection.Clinicians should prescribe blood-activating and stasis-eliminating herb in treating these two coalescent critical diseases as long as no contraindications exist.However,further studies are needed to validate our results.

关 键 词：BACTEREMIA MEDICINE Chinese traditional herbal medicine SEPSIS propensity-matched analysis 

分 类 号：R278[医药卫生—中医学]