非编码RNA在甲基苯丙胺诱导成瘾及神经毒性作用的研究进展  

Research progress of non⁃coding RNA in methamphetamine⁃induced addiction and neurotoxicity

作　　者：张树威 程浩 王浩伟 苗霖 李怡 官莉娜 曾晓锋 ZHANG Shuwei;CHENG Hao;WANG Haowei;MIAO Lin;LI Yi;GUAN Lina;ZENG Xiaofeng(Key Laboratory of Drug Dependence and Treatment,National Health Commission,School of Forensic Medicine,Kunming Medical University,Kunming 650500,China)

机构地区：[1]国家卫健委毒品依赖和戒治重点实验室,昆明医科大学法医学院,昆明650500

出　　处：《中国比较医学杂志》2024年第2期114-121,共8页Chinese Journal of Comparative Medicine

基　　金：国家自然科学基金(82160325,82060382);云南省科技厅-昆明医科大学应用基础研究联合专项(202001AY070001-177,202101AY070001-062);昆明医科大学研究生创新基金项目(2022S015)。

摘　　要：甲基苯丙胺(methamphetamine,METH)具有高度成瘾性和神经毒性,可导致滥用者的认知和记忆功能障碍。METH的危害不仅在于其本身的毒性,更在于吸毒者身心的高度依赖性,常造成精神障碍并引发暴力行为,给社会带来极大的安全隐患。非编码RNA(non⁃coding RNA,ncRNA)不编码蛋白质,是在转录后水平调控基因表达的重要因子。研究表明,ncRNA在甲基苯丙胺诱导的成瘾及神经毒性中发挥了重要的调控作用,但其具体机制尚不清楚。本文就目前ncRNA调控METH诱导成瘾及神经毒性的研究进展进行综述,以期为ncRNA作为METH滥用者的法医学鉴定指标和潜在的药物干预靶点提供参考。Methamphetamine(METH)is highly addictive and neurotoxic,which causes cognitive and memory dysfunction in abusers.The harm of METH lies not only in its own toxicity,but also in the high physical and mental dependence of drug addicts,often causing mental disorders and violent behavior,bringing great safety risks to society.Non⁃coding RNA(ncRNA)does not encode proteins and is an important factor in regulating gene expression at the post⁃transcriptional level.Studies have shown that ncRNA plays an important regulatory role in methamphetamine⁃induced addiction and neurotoxicity,but the specific mechanism is unclear.This article reviews the current research progress of ncRNA in regulating METH⁃induced addiction and neurotoxicity to provide a reference for ncRNA as a forensic identification index and potential therapeutic target for METH abusers.

关 键 词：甲基苯丙胺 非编码RNA 成瘾 神经毒性 

分 类 号：R-33[医药卫生]