经皮给药系统皮肤模型的研究进展  

Overview of in vitro skin models of transdermal drug delivery systems

作　　者：刘沿 胡小垒 许可洪 赵海荣 巫秀美 杨自忠 张成桂 赵昱 高鹏飞 LIU Yan;HU Xiaolei;XU Kehong;ZHAO Hairong;WU Xiumei;YANG Zizhong;ZHANG Chenggui;ZHAO Yu;GAO Pengfei(College of Pharmacy,Dali University,Dali 671000,China;Yunnan Provincial Key Laboratory of Entomological Biopharmaceutical R&D,Dali University,Dali 671000;National Joint Engineering Research Center for the Development of Medicinal Special Insects,Dali University,Dali 671000;College of Public Health,Dali University,Dali 671000)

机构地区：[1]大理大学药学院,云南大理671000 [2]大理大学云南省昆虫生物医药研发重点实验室,云南大理671000 [3]大理大学药用特种昆虫开发国家地方联合工程研究中心,云南大理671000 [4]大理大学公共卫生学院,云南大理671000

出　　处：《中国比较医学杂志》2024年第2期122-128,共7页Chinese Journal of Comparative Medicine

基　　金：国家自然科学基金(82160798,81960712,81260676);云南省重大科技专项计划—生物资源数字化开发应用(202002AA100007);中国国家留学基金(201708535007)。

摘　　要：经皮给药系统(transdermal drug delivery system,TDDS)的皮肤模型是指构建能够模拟人体皮肤结构和功能,并用于研究和评估药物在经皮给药过程中的吸收、渗透及药效等方面的实验模型。该模型可代替传统人体皮肤实验,减少药物开发过程中对人体皮肤的使用,为经皮制剂的研发提供一种便捷、可控且经济高效的方法。针对经皮给药系统的皮肤模型,本文从药物经皮吸收途径出发,对目前常用的动物皮肤模型、人工皮肤模型、重组人体皮肤模型进行介绍,并对其优缺点及应用进行了分析,为经皮制剂的研发提供参考。Skin modeling of transdermal drug delivery system refers to experimental models that mimic the structure and function of human skin to explore and evaluate absorption,penetration,and efficacy of medicines in transdermal drug delivery.It provides an alternative to traditional human skin experiments and reduces the use of human skin in medical research,which is convenient,controllable,and cost effective.For skin models of transdermal drug delivery systems,this article introduces commonly used animal skin models,artificial skin models,and recombinant human skin models from the perspective of the transdermal absorption pathway of medicines,and analyzes their advantages,disadvantages,and applications so provide references the research and development of transdermal formulations and topical therapies.

关 键 词：经皮给药系统 皮肤模型 应用特点 

分 类 号：R-33[医药卫生]