中医药干预白血病干细胞免疫逃逸研究进展  

Mechanism of leukemia stem cells immune escape by Traditional Chinese Medicine intervention

作　　者：章美玲[1] 崔亚茹[1] 陈抒鹏 罗钧允 曾英坚[1,2] ZHANG Meiling;CUI Yaru;CHEN Shupeng;LUO Junyun;ZENG Yingjian(Jiangxi University of Chinese Medicine,Nanchang 330000,China;the Affiliated Hospital of Jiangxi University of Chinese Medicine,Nanchang 330000)

机构地区：[1]江西中医药大学,南昌330000 [2]江西中医药大学附属医院,南昌330000

出　　处：《中国比较医学杂志》2024年第2期137-143,共7页Chinese Journal of Comparative Medicine

基　　金：国家自然科学基金(82260914);江西省自然科学基金面上项目(20192BAB205100);江西省中医药管理局临床研究基地(第二批)建设项目(赣中医药科教字〔2021〕3号)。

摘　　要：白血病是目前临床上高发的急危重症,病死率极高,其中白血病干细胞(leukemia stem cells,LSC)发生免疫逃逸是白血病诱导缓解后复发及进展的主要因素。中医药(Traditional Chinese Medicine,TCM)临床诊疗具有鲜明的辨证论治优势,基于“以平为期”的诊治目的,中医药辨治白血病强调恢复人体机能的“阴阳和谐”,有助于提高机体自身免疫力,符合干预肿瘤细胞免疫逃逸的机制。本文从文献研究及中医理论探讨中医药干预LSC免疫逃逸的机制及其研究进展。Leukemia is a critical disease with a high incidence and extremely high fatality rate.Immune escape by leukemia stem cells(LSC)is the main factor for recurrence and progression after remission.Clinical diagnosis and treatment by Traditional Chinese Medicine(TCM)have distinct advantages of syndrome differentiation and treatment.Based on the purpose of diagnosis and treatment,leukemia treatment by TCM emphasizes the harmony of yin and yang to restore human functions,which is conducive to improve autoimmunity and conforms to the mechanism of intervention for tumor cell immune escape.This article discusses the mechanism and research progress of TCM interventions in LSC immune escape based on literature and TCM theory.

关 键 词：中医药 白血病细胞 免疫逃逸 干预机制 

分 类 号：R-33[医药卫生]