AMPK:多样性调控机制与疾病治疗新视角  

AMPK:Diverse regulatory mechanisms and new perspectives for disease treatment

作　　者：宁静华 张鑫 张钰哲 NING Jinghua;ZHANG Xin;ZHANG Yuzhe(Basic Medicine Science College of Dali University,Dali 671000,China;Yunnan Key Laboratory for Screening of Pathogen Resistant Medicinal Plants,Dali 671000;Yunnan Provincial Key Laboratory of Entomological Biopharmaceutical,Dali 671000)

机构地区：[1]大理大学基础医学院,云南大理671000 [2]云南抗病原药用植物筛选重点实验室,云南大理671000 [3]云南省昆虫生物医药重点实验室,云南大理671000

出　　处：《中国比较医学杂志》2024年第2期167-178,共12页Chinese Journal of Comparative Medicine

基　　金：云南省地方高校联合专项面上项目(202001BA070001-064,202101BA070001-102);云南省教育厅科学研究基金项目(2023Y0950,2022Y80);云南省滇西抗病原植物资源筛选研究重点实验室开放项目(APKL2101);大理大学博士科研启动基金项目(KYBS2018012)。

摘　　要：单磷酸腺苷激活的蛋白激酶(AMP-activated protein kinase,AMPK)是一种保守的细胞能量感受器,在调控细胞生长、增殖、分化、自噬、磷酸化、串扰以及葡萄糖和脂质代谢等方面起着重要作用,当机体能量匮乏或某些极端情况时AMPK被激活,而在营养过剩时被抑制,以维持能量平衡。此外,AMPK信号通路介导铁死亡发生的调控机制也体现了其独特作用,AMPK在不同细胞器里发挥特殊调控功能为疾病治疗提供了新的方向。这也是预防疾病的治疗靶标,如生殖系统疾病、衰老、癌症、炎症和心脏功能障碍等。该文综述了细胞能量不平衡对机体微环境造成的损害,AMPK通过多样性信号调控机制激发了其在疾病和药物中的潜在治疗潜力,为不同系统疾病提供了治疗新思路。通过综述AMPK信号通路的多样性调节机制,为靶向AMPK的癌症治疗和其他疾病的治疗提供理论参考。AMP⁃activated protein kinase(AMPK)is a conserved cellular energy receptor that plays an important role in regulating cell growth,proliferation,differentiation,autophagy,phosphorylation,crosstalk,and glucose and lipid metabolism.AMPK is activated during low⁃energy or other extreme conditions,and it is suppressed by an excess of nutrients to maintain the energy balance.Additionally,the regulatory mechanism of the AMPK signaling pathway mediating ferroptosis reflects its unique role.AMPK plays a specialized regulatory function in various organelles,which provides a new direction for disease therapy.It is also a therapeutic target to prevent diseases such as reproductive system diseases,aging,cancer,inflammation and cardiac dysfunction.This article reviews cellular energy imbalance.AMPK stimulates its potential therapeutic potential in diseases and drugs through diverse signal regulatory mechanisms.It provides a new treatment for different system diseases.This review summarizes the diverse regulatory mechanisms of the AMPK signaling pathway and provides a theoretical reference for cancer therapy and other disease therapies targeting AMPK.

关 键 词：单磷酸腺苷激活的蛋白激酶 能量代谢 铁死亡 信号传导 治疗靶标 

分 类 号：R-33[医药卫生]