重视视网膜下注射技术的临床应用  

Clinical application of subretinal injection

作　　者：万光明[1] 王明阳 WAN Guangming;WANG Mingyang(Department of Ophthalmology,the First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,Henan Province,China)

机构地区：[1]郑州大学第一附属医院眼科,河南省郑州市450052

出　　处：《眼科新进展》2024年第4期253-257,共5页Recent Advances in Ophthalmology

基　　金：国家重点研发计划项目(编号:2022YFC2404203)。

摘　　要：视网膜下腔是位于视网膜色素上皮层和感光细胞层之间的潜在腔隙。视网膜下注射是将治疗药物输送到视网膜下腔的一种给药方式。与玻璃体内注射相比,视网膜下注射药物对视网膜光感受器细胞和视网膜色素上皮细胞的作用更直接、更有效。近年来,随着医疗技术的进步和手术器械的更新与发展,视网膜下注射的临床应用范围逐渐拓宽,已成为多种眼底疾病基因治疗和细胞治疗的重要给药方式,在玻璃体视网膜手术中的作用也日益显著。本文将从视网膜下注射的适应证、方法与技巧以及潜在风险与并发症等方面进行探讨。The subretinal space is a potential area between the retinal pigment epithelium layer and the photoreceptor layer.Subretinal injection is a way of drug administration to the subretinal space.Compared with intravitreal injection,subretinal injection allowed drugs to take more direct and effective action on retinal photoreceptor cells and retinal pigment epithelial cells.In recent years,thanks to advances in medical technology and surgical instrumentation subretinal injection realizes a gradually expanded clinical application,becoming an important drug delivery method for gene therapy and cell therapy of various fundus oculi diseases and playing an increasingly prominent role in vitreoretinal surgery.This article will explore the indications,techniques,potential risks,and complications of subretinal injection.

关 键 词：视网膜下注射 基因治疗 细胞治疗 玻璃体视网膜手术 

分 类 号：R774.1[医药卫生—眼科]