术前辅助栓塞联合开放手术治疗实性血管母细胞瘤疗效的Meta分析  

A Meta⁃analysis on the outcome of Solid Hemangioblastomas treated by surgery combined with preoperative endovascular embolization

作　　者：李祥骥[1] 刘彦廷[1] 万志先[1] 朱岳峰 田春雷[1] LI Xiangji;LIU Yanting;WAN Zhixian;ZHU Yuefeng;TIAN Chunlei(Institute of Neurology,First College of Clinical Medical Science China Three Gorges University&Yichang Center People’s Hospital,Hubei,Yichang 443003,China)

机构地区：[1]三峡大学神经病学研究所,三峡大学第一临床医学院/湖北省宜昌市中心人民医院神经外科,湖北宜昌443003

出　　处：《临床外科杂志》2023年第12期1130-1133,共4页Journal of Clinical Surgery

摘　　要：目的评估术前栓塞辅助开放手术治疗实性血管母细胞瘤的安全性及有效性。方法通过检索万方数据库、中国期刊网全文数据库、维普数据库、PubMed、Medline、Springer等中外数据库,获取关于术前栓塞联合开放手术治疗与单纯开放手术治疗实性血管母细胞瘤的文献,由2名医师独立选择、提取并交叉核对数据,并对其方法学进行质量评价,使用RevMan5.3软件对筛选之后符合纳入及排除标准的文献进行Meta分析。结果共有8篇文献纳入Meta分析,结果显示,实性血管母细胞瘤术前辅助栓塞联合手术治疗与单纯手术治疗组手术时间、失血量、输血量和手术全切率比较,差异有统计学意义(P<0.00001,WMD(Weighted Mean Difference,加权均数差)=-1.18,95%CI为-1.16,-0.71;P<0.00001,WMD=-464.17,95%CI为[-492.17,-437.24];P<0.00001,WMD=-238.81,95%CI为-282.84,-194.77;P<0.006,RR(Risk Ratio,相对危险度)=1.17,95%CI为[1.05,1.31])。结论实性血管母细胞瘤行术前辅助栓塞有利于缩短手术时间,减少术中失血量与输血量,提高肿瘤的全切率。ed for Meta⁃analysis by RevMan 5.3.Results 8 randomized controlled trails(RCT)were included.Selected analysis of embolized and non⁃embolized groups of Solid Hemangioblastomas were observed for variables of clinical efficacy in surgery time,number of blood loss and transfusions,complete resection,there were statistical difference.(P<0.00001,WMD=-1.18,95%CI[-1.16,-0.71];P<0.00001,WMD=-464.17,95%CI[-492.17,-437.24];P<0.00001,WMD=-238.81,95%CI[-282.84,-194.77];P<0.006,RR=1.17,95%CI[1.05,1.31]).Conclusion The preoperative endovascular embolization is beneficial for Hemangioblastomas because it can shorten the time of surgery,diminish the necessity of intra⁃operative blood loss and transfusion,it also raises the ratio of complete resection of Solid Hemangioblastomas.

关 键 词：术前栓塞 手术 实性 血管母细胞瘤 META分析 

分 类 号：R732.2[医药卫生—肿瘤]