肝细胞癌行根治性肝切除术后复发治疗新进展  

Advances in the treatment of recurrence after curative liver resection for hepatocellular carcinoma

作　　者：丛赟 李国煜 王丹妮 邵英梅[1,4] 吐尔干艾力·阿吉 Cong Yun;Li Guoyu;Wang Danni;Shao Yingmei;Tuerganaili·Aji(Department of Hepatobiliary Hydatid Disease Surgery,the First Affiliated Hospital of Xinjiang Medical University,Urumqi 830054,China;Digestive Vascular Center Pancreatic Surgery,the First Affiliated Hospital of Xinjiang Medical University,Urumqi 830054,China;Department of Dermatology and Venereology,the First Affiliated Hospital of Xinjiang Medical University,Urumqi 830054,China;State Key Laboratory of Central Asian High-prealence Disease Etiology and Prevention,Xinjiang Medical University,Urumqi 830054,China)

机构地区：[1]新疆医科大学第一附属医院肝胆包虫病外科,乌鲁木齐830054 [2]新疆医科大学第一附属医院消化血管中心胰腺外科,乌鲁木齐830054 [3]新疆医科大学第一附属医院皮肤与性病学科,乌鲁木齐830054 [4]新疆医科大学省部共建中亚高发病成因与防治国家重点实验室,乌鲁木齐830054

出　　处：《中华普通外科学文献（电子版）》2024年第2期137-141,共5页Chinese Archives of General Surgery(Electronic Edition)

基　　金：国家科技重大专项(民口)课题项目(2018ZX10301-201-007);新疆维吾尔自治区高校科研计划自然科学重点项目(XJEDU2021I016);省部共建中亚高发病成因与防治国家重点实验室开放课题项目(SKL-HIDCA-2020-BC)。

摘　　要：根治性肝切除术后的高复发率和转移率一直影响着肝细胞癌(HCC)患者的生存预后,因此降低复发率已成为治疗的关键。手术治疗目前仍然是肝癌复发最有效的治疗方式之一。近年来,靶向治疗、免疫检查点抑制剂为代表的系统抗肿瘤治疗技术展现了巨大潜力,单独的局部治疗和联合应用辅助治疗的策略也取得了巨大进展,提高了患者的无病生存期和总生存期。本文回顾HCC复发后的手术治疗、局部治疗、抗病毒治疗和系统抗肿瘤治疗方面的最新进展,为有效预防和治疗HCC复发总结经验依据。The high rates of recurrence and metastasis after radical liver resection have always affected the survival rate and prognosis of patients with hepatocellular carcinoma(HCC).Therefore,it is vital to reduce the recurrence rates.Surgical treatment is still one of the most effective approaches for HCC recurrence.In recent years,systemic anti-tumor therapies,represented by targeted therapy and immune checkpoint inhibitors,have shown tremendous potential.Significant progress has also been made in independently local treatment and combination therapies,improving patients’disease-free survival and overall survival.This article reviews the latest development in surgical treatment,local treatment,antiviral therapy,and systemic anti-tumor therapy for HCC recurrence,providing a summary of experiential evidence for effective prevention and treatment of HCC recurrence.

关 键 词：癌 肝细胞 复发转移 预防 治疗方案 肝切除术 

分 类 号：R735.7[医药卫生—肿瘤]