基于meta分析的鸦胆子油乳注射液联合长春瑞滨联合顺铂/卡铂方案治疗非小细胞肺癌临床效果和安全性  

Meta-analysis of Brucea javanica Oil Emulsion Injection combining Navelbine plus Cisplatin/Carboplatin chemotherapy in the clinical efficacy and safety of non-small cell lung cancer

作　　者：李珂心 袁晓燕[2] 李明娟 张珞喻 施蕾 李欣坪 LI Kexin;YUAN Xiaoyan;LI Mingjuan;ZHANG Luoyu;SHI Lei;LI Xinping(College of Pharmacy,Dali University,Yunnan Province,Dali671003,China;Department of Pharmacy,Panzhihua Central Hospital,Sichuan Province,Panzhihua617067,China)

机构地区：[1]大理大学药学院,云南大理671003 [2]四川省攀枝花市中心医院药学部,四川攀枝花617067

出　　处：《中国当代医药》2024年第7期7-13,共7页China Modern Medicine

基　　金：四川省医院协会青年药师科研专项资金项目(22017)。

摘　　要：目的系统评价鸦胆子油乳注射液联合长春瑞滨联合顺铂/卡铂(NP)方案化疗治疗非小细胞肺癌(NSCLC)的临床疗效和安全性。方法检索中国知网、SinoMed、VIP、万方数据库、the Cochrane Library、PubMed、Embase数据库,搜索有关鸦胆子油乳注射液联合NP化疗治疗NSCLC的随机对照试验,检索时限均为从建库至2023年5月22日,由2名研究者独立筛选文献,提取资料并评价纳入研究的偏倚风险后,采用RevMan 5.4.1及Stata 15.1软件进行meta分析和发表偏倚检验。结果共纳入12项随机对照试验,累计801例患者。Meta分析结果显示,对比仅使用NP化疗方案,鸦胆子油乳注射液联合NP方案化疗治疗NSCLC可提高临床受益率(RR=2.00,95%CI=1.34~2.98,P=0.0006),症状总改善率(RR=1.53,95%CI=1.19~1.96,P=0.0009)和生活质量改善率(RR=2.58,95%CI=1.95~3.41,P<0.00001),降低患者白细胞减少发生率(RR=0.73,95%CI=0.62~0.86,P<0.0001)。结论联合用药方案相较于单用NP化疗方案疗效更佳,且可提高患者临床受益率、症状总改善率,改善患者生活质量,增强患者免疫功能。但本研究结论仍需未来多中心、大样本随机盲法试验数据的支持。Objective To systematically evaluate the clinical efficacy of Brucea javanica Oil Emulsion Injection combining Navelbine plus Cisplatin/Carboplatin(NP)chemotherapy in the treatment of non-small cell lung cancer(NSCLC).Methods CNKI,SinoMed,VIP,WanFang Data,the Cochrane Library,PubMed and Embase databases were searched.Randomized controlled trials of Brucea javanica Oil Emulsion Injection combined with NP chemotherapy in the treatment of NSCLC were searched from the establishment of the database to May 22,2023.Two reviewers independently screened the literature,extracted data,and assessed the risk of bias of the included studies.Then,meta-analysis and publication bias test was performed by using RevMan 5.4.1and Stata 15.1 softwares.Results A total of 12 randomized controlled trials were included,with 801 patients.The result showed that,compared with only NP chemotherapy,Brucea javanica Oil Emulsion Injection combining NP chemotherapy could improve the clinical benefit rate(RR=2.00,95%CI=1.34-2.98,P=0.0006),total improvement rate of symptoms(RR=1.53,95%CI=1.19-1.96,P=0.0009)and the term of performance status(RR=2.58,95%CI=1.95-3.41,P<0.00001),reduce the incidence of leukopenia(RR=0.73,95%CI=0.62-0.86,P<0.0001).Conclusion Compared with only NP chemotherapy,Brucea javanica Oil Emulsion Injection combining NP chemotherapy in the treatment of NSCLC can significantly improve the clinical benefit rate,total improvement rate of symptoms,performance status,and reduce the incidence of leukopenia in patients.However,the conclusions of this study need to be confirmed by more well-designed,multi-center,large-sample sizes,and randomized controlled trails.

关 键 词：鸦胆子油乳注射液 非小细胞肺癌 NP化疗方案 META分析 

分 类 号：R734.2[医药卫生—肿瘤]