胃癌患者术前血清CA72-4、CYFRA21-1水平与生存预后的关系  

Preoperative Serum CA72-4,CYFRA21-1 Levels and Survival Prognosis in Patients with Gastric Cancer

作　　者：张旭[1] 南京柱[1] 魏雪梅 朱琳[1] 高艳红[1] ZHANG Xu;NAN Jingzhu;WEI XueMei;ZHU Lin;GAO Yanhong(Department of Clinical Laboratory,the First Medical Center,Chinese PLA General Hospital,Beijing 100853,China)

机构地区：[1]解放军总医院第一医学中心检验科,北京100853

出　　处：《标记免疫分析与临床》2024年第1期22-27,共6页Labeled Immunoassays and Clinical Medicine

基　　金：国家重点研发计划课题(编号:2017YFF0205401)。

摘　　要：目的 通过研究不同肿瘤标志物水平、不同病理状态下胃癌患者的预后生存情况,找到影响患者生存预后的危险因素。方法 收集2018年12月至2021年1月在解放军总医院第一医学中心行手术治疗的164例胃癌患者临床资料,并随访患者生存情况,分析影响胃癌患者生存的风险因素。结果 生存时间≤2年的胃癌患者血清CYFRA21-1、PGII水平明显高于生存时间>2年组,差异具有统计学意义(P=0.002、0.023)。胃癌患者在CA72-4≤10U/mL、CYFRA21-1≤4.0ng/mL、TNM分期为I+II期、Lauren分型为肠型、非印戒细胞癌中1、2、3年生存率较高,在CA72-4>10U/mL、CYFRA21-1>4.0ng/mL、TNM分期为III+IV期、Lauren分型为弥散型、印戒细胞癌中生存率较低,差异具有统计学意义(P=0.0001、0.0007、<0.0001、<0.0001、0.0002)。血清CA72-4、CYFRA21-1水平、印戒细胞癌、TNM分期是影响胃癌患者生存的风险因素(P=0.001、<0.001、<0.001、<0.001)。结论 血清高CA72-4、CYFRA21-1水平、印戒细胞癌、TNM分期较晚是胃癌患者生存预后的风险因素。Objective In the current study,by studying the prognosis and survival of patients with gastric cancer under different levels of tumor markers and different pathological states,the risk factors affecting the survival and prognosis of patients were identified.Methods The clinical data of 164 patients with gastric cancer who underwent surgical treatment in the First Medical Center of the PLA General Hospital from December,2018 to January,2021 were collected,and the survival conditions of these patients were followed up to analyze the risk factors affecting the survival of patients with gastric cancer.Results Serum CYFRA21-1 and PG-Ⅱ levels of gastric cancer patients with survival time≤2 years were significantly higher than those of patients with survival time>2 years(P=0.002,0.023).1,2,and 3-year survival rates of gastric cancer patients were higher in CA72-4≤10U/mL,CYFRA21-1≤4.0ng/mL,TNM stage Ⅰ+Ⅱ,Lauren’s intestinal type,and non-signet-ring cell carcinoma group.For patients with CA72-4>10U/mL,CYFRA21-1>4.0ng/mL,TNM stage Ⅲ+Ⅳ,and Lauren’s type which was diffuse type,signet ring cell carcinoma was lower for the survival rates,and the differences were statistically significant(P=0.0001,0.0007,<0.0001,<0.0001,0.0002).Serum CA72-4,CYFRA21-1 levels,signet ring cell carcinoma and TNM stage were risk factors affecting the survival of patients with gastric cancer(P=0.001,<0.001,<0.001,<0.001).Conclusion High serum CA72-4,CYFRA21-1 levels,signet ring cell carcinoma and late TNM staging are risk factors for survival and prognosis in patients with gastric cancer.

关 键 词：胃癌 糖类抗原72-4 细胞角质素片段19 印戒细胞癌 TNM分期 

分 类 号：R735.2[医药卫生—肿瘤]