首发精神分裂症患者血清S100B蛋白、NT-3、GFAP水平变化及与认知功能和预后的关系  

Changes of Serum S100B Protein,NT-3 and GFAP Levels in Patients with First-episode Schizophrenia and Their Relationships with Cognitive Function and Prognosis

作　　者：史心怡 种小妮 卢梅 SHI Xinyi;CHONG Xiaoni;LU Mei(Department of Mental Health,Baoji Central Hospital of Shaanxi Province,Baoji 721000,China;Department of Psychiatry,Baoji Rehabilitation Hospital,Baoji 721000,China)

机构地区：[1]陕西省宝鸡市中心医院精神卫生科,陕西宝鸡721000 [2]陕西省宝鸡市康复医院精神科,陕西宝鸡721000

出　　处：《标记免疫分析与临床》2024年第1期94-98,共5页Labeled Immunoassays and Clinical Medicine

基　　金：陕西省重点研发计划(编号:2020 SF-361)。

摘　　要：目的 探讨首发精神分裂症患者血清S100钙结合蛋白B(S100B)、神经营养因子3(NT-3)、胶质纤维酸性蛋白(GFAP)水平变化及与认知功能和预后的关系。方法 回顾性分析2019年2月至2022年2月在我院进行诊治的100例首发精神分裂症患者的临床资料,将其作为观察组,根据认知功能成套测验(MCCB)结果将其分为轻度认知受损组(n=42,MCCB≥200分)、重度认知受损组(n=58,MCCB评分<200分),根据大体评定量表(GAS)评分将其分为预后良好组(n=72,GAS≥61分)、预后不良组(n=28,GAS<61分),另选取同期50例健康体检者作为对照组。比较不同组别间血清S100B蛋白、NT-3、GFAP水平差异,并分析其与认知功能和预后的关系。结果 观察组血清S100B蛋白、GFAP水平均高于对照组,血清NT-3水平低于对照组(P<0.05)。轻度认知受损组血清S100B蛋白、GFAP水平均低于重度认知受损组,血清NT-3水平高于重度认知受损组(P<0.05)。预后良好组血清S100B蛋白、GFAP水平均低于预后不良组,血清NT-3水平高于预后不良组(P<0.05)。Pearson相关性检验显示,血清S100B蛋白、GFAP水平与MCCB评分均呈负相关(r=-0.288,-0.267,P<0.05),血清NT-3水平与MCCB评分呈正相关(r=0.380,P<0.05)。ROC曲线分析显示,血清S100B蛋白、NT-3、GFAP水平在预测首发精神分裂症患者预后不良中具有极高的价值。结论 首发精神分裂症患者血清S100B蛋白、GFAP水平升高、血清NT-3水平降低与认知功能障碍存在相关性,有助于疾病的早期诊断,上述3项指标在预测患者预后不良中具有极高的价值,可用于评估预后情况。Objective To investigate changes of serum S100 calcium-binding protein B(S100B),neurotrophic factor 3(NT-3)and glial fibrillary acidic protein(GFAP)levels in patients with first-episode schizophrenia and their relationships with cognitive function and prognosis.Methods The clinical data of 100 patients with first-episode schizophrenia who were diagnosed and treated in our hospital from February,2019 to February,2022 were retrospectively analyzed.These patients were selected as the observation group.The selected patients were further divided into the mild cognitive impairment group(n=42,MCCB≥200 points)and severe cognitive impairment group(n=58,MCCB score<200 points).Patients were also divided into prognosis groups according to the gross rating scale(GAS):score good group(n=72,GAS≥61 points)and poor prognosis group(n=28,GAS<61 points),while another 50 healthy subjects during the same period were selected as the control group.The differences in serum S100B protein,NT-3 and GFAP levels between different groups were compared,and their relationships with cognitive function and prognosis was analyzed.Results Serum levels of S100B protein and GFAP in the observation group were higher than those in the control group,and the serum NT-3 level was lower than that in the control group(P<0.05).Levels of serum S100B protein and GFAP in the mild cognitive impairment group were lower than those in the severe cognitive impairment group,while the serum NT-3 level was higher than that in the severe cognitive impairment group(P<0.05).Serum levels of S100B protein and GFAP in the good prognosis group were lower than those in the poor prognosis group,while the serum NT-3 level was higher than that in the poor prognosis group(P<0.05).Pearson correlation test showed that serum S100B protein and GFAP levels were negatively correlated with MCCB score(r=-0.288,-0.267,P<0.05),while serum NT-3 level was positively correlated with MCCB score(r=0.380,P<0.05).ROC curve analysis showed that serum S100B protein,NT-3,and GFAP levels had extrem

关 键 词：首发精神分裂症 钙结合蛋白 神经营养因子3 胶质纤维酸性蛋白 认知功能 预后 

分 类 号：R749.3[医药卫生—神经病学与精神病学]