血清髓过氧化物酶与脑小血管病患者认知障碍的相关性分析  

Analysis on correlation between serum myeloperoxidase and cognitive impairment in patients with cerebral small vessel disease

作　　者：孙美玉 张金洪 赵文义 王红 曹娟 SUN Meiyu;ZHANG Jinhong;ZHAO Wenyi;WANG Hong;CAO Juan(Department of Neurology,Cangzhou Municipal People's Hospital,Cangzhou,Hebei 061000,China)

机构地区：[1]河北省沧州市人民医院神经内科,河北沧州061000

出　　处：《检验医学与临床》2024年第7期875-879,共5页Laboratory Medicine and Clinic

基　　金：河北省医学科学研究课题(20220311)。

摘　　要：目的探讨血清髓过氧化物酶(MPO)与脑小血管病(CSVD)患者认知障碍的相关性。方法选取该院2021年3月至2022年12月收治的125例CSVD患者作为研究组。同期纳入在该院体检的健康人群125例作为对照组。使用简易精神评估量表(MMSE)和蒙特利尔认知评估量表(MoCA)评估研究组患者认知功能,并分为认知障碍组与认知正常组。检测各组血清MPO水平。采用Spearman相关分析血清MPO水平与CSVD患者认知障碍的相关性,采用Logistic回归分析CSVD患者认知障碍的影响因素,采用受试者工作特征(ROC)曲线分析血清MPO对认知障碍的预测价值。结果125例CSVD患者的认知障碍发生率为38.40%(48/125)。研究组血清MPO水平[(265.60±34.39)μg/L]较对照组[(241.36±27.58)μg/L]高,差异有统计学意义(P<0.05)。认知障碍组血清同型半胱氨酸(Hcy)、超敏C反应蛋白(hs-CRP)、MPO水平较认知正常组高,差异有统计学意义(P<0.05)。Hcy、hs-CRP、MPO水平与CSVD患者认知障碍呈正相关(r s=0.430、0.345、0.448,P<0.001)。Logistic回归分析结果显示,血清Hcy、hs-CRP、MPO是CSVD患者发生认知障碍的影响因素(P<0.05)。ROC曲线分析结果显示,血清Hcy、hs-CRP、MPO单独及联合检测预测CSVD患者发生认知障碍的曲线下面积(AUC)分别为0.752、0.669、0.778、0.867。结论血清MPO水平对CSVD患者发生认知障碍具有预测价值,可作为辅助预测的指标。血清MPO水平升高则提示CSVD患者发生认知障碍风险较高。Objective To explore the correlation between serum myeloperoxidase(MPO)level and cognitive impairment in the patients with cerebral small vessel disease(CSVD).Methods A total of 125 patients with CSVD admitted and treated in this hospital from March 2021 to December 2022 were selected as the study group.At the same time,125 healthy people undergoing physical examination in this hospital were included as the control group.The mini-mental state examination(MMSE)and Montreal cognitive assessment(MoCA)were used to evaluate the cognitive function of the patients in the study group,and the patients were divided into the cognitive impairment group and cognitive normal group.Serum MPO level in all groups was detected.The correlation between serum MPO level and cognitive impairment in the patients with CSVD was analyzed by the Spearman correlation.The Logistic regression was used to analyze the influencing factors of cognitive impairment in CSVD patients.The receiver operating characteristic(ROC)curve was used to analyze the predictive value of serum MPO for cognitive impairment.Results The incidence rate of cognitive impairment in 125 patients with CSVD was 38.40%(48/125).The serum MPO level in the study group was higher than that in the control group[(265.60±34.39)μg/L vs.(241.36±27.58)μg/L,P<0.05].The levels of serum homocysteine(Hcy),high-sensitivity C-reactive protein(hs-CRP)and MPO in the cognitive impairment group were higher than those in the cognitive normal group,and the differences were statistically significant(P<0.05).The levels of Hcy,hs-CRP and MPO were positively correlated with the cognitive impairment in CSVD patients(r s=0.430,0.345,0.448,P<0.001).Logistic regression analysis results showed that serum Hcy,hs-CRP and MPO were the influencing factors for cognitive impairment occurrence in CSVD patients(P<0.05).The ROC curve analysis results showed that the areas under the curves(AUC)of serum Hcy,hs-CRP and MPO levels alone and in combination for predicting cognitive impairment occurrence in CSVD patie

关 键 词：脑小血管病 认知障碍 髓过氧化物酶 超敏C反应蛋白 同型半胱氨酸 预测价值 

分 类 号：R743.3[医药卫生—神经病学与精神病学]