盐酸齐拉西酮联合丙戊酸钠对双相Ⅰ型障碍躁狂发作患者PANSS评分及微炎症指标的影响  

Effect of ziprasidone hydrochloride combined with sodium valproate on PANSS score and micro inflammatory indicators in patients with bipolar typeⅠmanic episode

作　　者：钟伦淳 谢宇花 赖忠红 何海英 ZHONG Lunchun;XIE Yuhua;LAI Zhonghong;HE Haiying(Department of Emotional Disorders,Ganzhou Municipal Third People's Hospital,Ganzhou,Jiangxi 341000,China;Department of Psychosomatic Medicine,Ganzhou Municipal Third People's Hospital,Ganzhou,Jiangxi 341000,China)

机构地区：[1]江西省赣州市第三人民医院情感障碍科,江西赣州341000 [2]江西省赣州市第三人民医院心身医学科,江西赣州341000

出　　处：《检验医学与临床》2024年第7期945-947,953,共4页Laboratory Medicine and Clinic

基　　金：江西省赣州市指导性科技计划项目(GZ2022ZSF292)。

摘　　要：目的探讨双相Ⅰ型障碍(BP-Ⅰ)躁狂发作患者采用丙戊酸钠、盐酸齐拉西酮联合治疗的效果。方法按照随机数字表法将该院2022年1月至2023年1月收治的92例BP-Ⅰ躁狂发作患者分为对照组和观察组,各46例。对照组采用丙戊酸钠治疗,观察组在对照组基础上加用盐酸齐拉西酮治疗,两组均治疗8周。比较两组倍克-拉范森躁狂量表(BRMS)评分、阳性与阴性症状量表(PANSS)评分、微炎症指标水平及不良反应发生情况。结果治疗后,两组PANSS评分及BRMS评分均降低(P<0.05),且观察组比对照组更低(P<0.05);治疗后,两组血清肿瘤坏死因子-α、白细胞介素-1β及白细胞介素-1水平均降低(P<0.05),且观察组比对照组更低(P<0.05);两组不良反应发生情况比较,差异无统计学意义(P>0.05)。结论BP-Ⅰ躁狂发作患者采用丙戊酸钠、盐酸齐拉西酮联合治疗可减轻躁狂程度,改善精神症状,调节微炎症指标水平,且未增加不良反应,安全性好。Objective To explore the efficacy of combined treatment of sodium valproate and ziprasidone hydrochloride in the patients with bipolar disorder typeⅠ(BP-Ⅰ)manic episode.Methods Ninety-two patients with BP-Ⅰmanic episodes admitted and treated in this hospital from January 2022 to January 2023 were divided into control group and observation group by using the random number table method,46 cases in each group.The control group was treated with sodium valproate,while the observation group was treated with ziprasidone hydrochloride on the basis of the control group.Both groups were treated for 8 weeks.The Bech-Rafaelsdn Mania Rating Scale(BRMS)score,Positive and Negative Symptom Scale(PANSS)score,micro inflammatory markers levels and the occurrence of adverse reactions were compared between the two groups.Results After treatment,the PANSS score and BRMS score in both groups were decreased(P<0.05),moreover the scores in the observation group were lower the those in the control group(P<0.05);after treatment,the levels of serum tumor necrosis factor-α,interleukin-1β and interleukin-1 after treatment in the two groups were decreased(P<0.05),moreover the observation group was lower than those in the control group(P<0.05);there was no statistically significant difference in the occurrence of adverse reactions between the two groups(P>0.05).Conclusion The combination treatment of sodium valproate and ziprasidone hydrochloride in the patients with BP-Ⅰmanic episodes could reduce the degree of mild mania,improve the mental symptoms,regulate the micro inflammatory indicators levels without increasing adverse reactions and with good safety.

关 键 词：双相Ⅰ型障碍 躁狂 丙戊酸钠 盐酸齐拉西酮 炎症指标 

分 类 号：R749.41[医药卫生—神经病学与精神病学]