Progress,implications,and challenges in using humanized immune system mice in CAR-T therapy-Application evaluation and improvement  

作　　者：Hanwei Yue Lin Bai 

机构地区：[1]NHC Key Laboratory of Human Disease Comparative Medicine,Institute of Laboratory Animal Sciences,CAMS and PUMC,Chao-yang District,Beijing,China

出　　处：《Animal Models and Experimental Medicine》2024年第1期3-11,共9页动物模型与实验医学（英文）

基　　金：CAMS Innovation Fund for Medical Sciences,Grant/Award Number:2021-I2M-1-035;National Key Research and Development Project,Grant/Award Number:2022YFA1103803。

摘　　要：In recent years,humanized immune system(HIS)mice have been gradually used as models for preclinical research in pharmacotherapies and cell therapies with major breakthroughs in tumor and other fields,better mimicking the human immune system and the tumor immune microenvironment,compared to traditional immunodeficient mice.To better promote the application of HIS mice in preclinical research,we se-lectively summarize the current prevalent and breakthrough research and evaluation of chimeric antigen receptor(CAR)-T cells in various antiviral and antitumor treat-ments.By exploring its application in preclinical research,we find that it can better reflect the actual clinical patient condition,with the advantages of providing high-efficiency detection indicators,even for progressive research and development.We believe that it has better clinical patient simulation and promotion for the updated design of CAR-T cell therapy than directly transplanted immunodeficient mice.The characteristics of the main models are proposed to improve the use defects of the existing models by reducing the limitation of antihost reaction,combining multiple models,and unifying sources and organoid substitution.Strategy study of relapse and toxicity after CAR-T treatment also provides more possibilities for application and development.

关 键 词：ANTITUMOR ANTIVIRAL CAR-T humanized immune system model humanized mice preclinical research 

分 类 号：Q95-33[生物学—动物学]