腺嘌呤核苷酸转位酶:生理功能及在疾病发生中的病理意义  

Adenine nucleotide translocase:physiological functions and pathological significance in disease occurrence

作　　者：胡永灿 吕凌[1] HU Yongcan;LU Ling(Department of Hepatobiliary Surgery,the First Affiliated Hospital of Nanjing Medical University,Nanjing 210029,China)

机构地区：[1]南京医科大学第一附属医院肝胆外科,江苏南京210029

出　　处：《南京医科大学学报（自然科学版）》2024年第4期546-552,566,共8页Journal of Nanjing Medical University(Natural Sciences)

基　　金：国家自然科学基金(81971495)。

摘　　要：腺嘌呤核苷酸转位酶(adenine nucleotide translocase,ANT)对线粒体完整性和生物能量代谢至关重要。ANT有4种异构体,生理情况下ANT主要参与膜两侧的腺嘌呤核苷二磷酸/腺嘌呤核苷三磷酸(adenosine diphosphate/adenosine triphosphate,ADP/ATP)交换,可能是构成线粒体渗透性转运孔(mitochondrial permeability transition pore,mPTP)的主要成分,并参与细胞凋亡和质子泄漏过程。ANT损伤引起线粒体功能障碍,在代谢性疾病、心肌病及肿瘤发生进展中有着重要的病理意义,文章总结了近几年有关ANT的研究进展和知识,旨在为靶向ANT的疾病治疗提供新思路。Adenine nucleotide translocases(ANTs)are crucial for mitochondrial integrity and bioenergetic metabolism.There are four isoforms of ANTs.Under physiological conditions,ANTs primarily engage in the exchange of adenosine diphosphate(ADP)and adenosine triphosphate(ATP)across mitochondrial membranes.ANT isoforms are also potentially significant components of the mitochondrial permeability transition pore(mPTP),contributing to processes such as cellular apoptosis and proton leakage.Impairment of ANTs leads to mitochondrial dysfunction,which holds significant pathological implications in metabolic diseases,cardiomyopathies,and cancer progression.This review summarizes recent advancements and knowledge regarding ANTs,aiming to offer new insights into potential therapeutic strategies targeting ANTs in diseases.

关 键 词：腺嘌呤核苷酸转位酶 代谢性疾病 恶性肿瘤 心肌病 线粒体 ADP/ATP载体 腺嘌呤核苷酸载体 

分 类 号：R363.1[医药卫生—病理学]