结直肠癌对肥胖和非肥胖患者骨骼肌萎缩的影响  

Impact of colorectal cancer on skeletal muscle atrophy in patients with and without obesity

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作  者:万谦益 赵锐[1] 陈亿[1] 宋应寒[2] 伍晓汀[1] Wan Qianyi;Zhao Rui;Chen Yi;Song Yinghan;Wu Xiaoting(Division of Gastrointestinal Surgery,Department of General Surgery,West China Hospital,Sichuan University,Chengdu 610041,China;Department of day surgery center,West China Hospital,Sichuan University,Chengdu 610041,China)

机构地区:[1]四川大学华西医院普外科胃肠外科病房,成都610041 [2]四川大学华西医院日间手术中心,成都610041

出  处:《中华普通外科杂志》2024年第3期188-191,共4页Chinese Journal of General Surgery

基  金:四川省科技计划项目重点研发项目(2022YFS0230);中国博士后科学基金第5批特别资助(站前)项目(2023TQ0225)。

摘  要:目的探究肥胖个体在结直肠癌影响下骨骼肌萎缩程度是否比非肥胖个体更严重。方法收集2020年7月至2021年12月在本科行结直肠癌根治术患者的临床资料。纳入64例肥胖患者并根据倾向评分匹配64例非肥胖患者,同时在非肿瘤患者中收集51例肥胖患者并匹配51例非肥胖患者,分析比较纳入患者腰肌指数。结果无论性别和体重,结直肠癌患者的腰肌指数均低于相应非肿瘤患者(均P<0.05)。结直肠癌患者中肥胖患者的腰肌指数均显著低于非肥胖患者(均P<0.05)。结论结直肠癌对肥胖个体骨骼肌萎缩的影响程度大于正常体重个体,对合并肥胖的结直肠癌患者应更加全面地评估其骨骼肌状态。Objective To explore whether the degree of skeletal muscle atrophy in obese individuals under the influence of colorectal cancer is more severe than that in non-obese individuals.Methods The clinical data of patients who underwent radical resection of colorectal cancer in our department from Jul 2020 to Dec 2021 was collected.Sixty-four obese patients were included and 64 non-obese patients were matched according to propensity score.At the same time,51 obese patients were collected from non-tumor patients and matched with 51 non-obese patients.The psoas muscle index(PMI)of included patients was analyzed and compared.Results The PMI of patients with colorectal cancer was significantly lower than that of corresponding non-tumor patients,regardless of gender and body weight(both P<0.05).The PMI of obese patients with colorectal cancer was significantly lower than that of non-obese patients(P<0.05).Conclusions The impact of colorectal cancer on skeletal muscle atrophy in obese individuals is greater than that in normal weight individuals.Therefore,the skeletal muscle status of obese patients with colorectal cancer should be evaluated more comprehensively.

关 键 词:肥胖 结直肠肿瘤 少肌症 

分 类 号:R735.34[医药卫生—肿瘤]

 

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