细胞膜修饰纳米粒子治疗脑部恶性肿瘤的研究进展  

Recent advance in cell membrane-modified nanoparticles for malignant brain tumor

作　　者：杨晶 孙逸初 梁飞 沈自强 夏铀铀 Yang Jing;Sun Yichu;Liang Fei;Shen Ziqiang;Xia Youyou(Department of Radiotherapy for Tumors,Affiliated Lianyungang Hospital of Xuzhou Medical University(First People's Hospital of Lianyungang),Lianyungang 222000,China;Lianyungang Clinical College of Nanjing Medical University(First People's Hospital of Lianyungang),Lianyungang 222000,China)

机构地区：[1]徐州医科大学附属连云港医院(连云港市第一人民医院)肿瘤放疗科,连云港222000 [2]南京医科大学连云港临床医学院(连云港市第一人民医院),连云港222000

出　　处：《中华神经医学杂志》2024年第2期186-191,共6页Chinese Journal of Neuromedicine

基　　金：江苏省连云港市科技计划重点研发计划(SF2347);江苏省高校重点实验室开放研究课题项目(XZSYKF2022042)。

摘　　要：细胞膜修饰纳米粒子(NPs)作为一种新型的治疗脑部恶性肿瘤的手段,近年来受到广泛关注。该方法通过保留源细胞膜的特性,提高了NPs的靶向性、生物相容性和体内循环时间,可确保药物高效作用于颅内病灶。本文围绕近年该领域研究进展,尤其是细胞膜修饰NPs穿透血脑屏障、免疫逃逸、药物输送的优势,以及不同细胞膜修饰NPs的效果进行综述,以期为脑部恶性肿瘤的治疗提供新的视角。Cell membrane-modified nanoparticles(NPs)have attracted widespread attention as a new approach for malignant brain tumors in recent years.This method can enhance the targeting,biocompatibility,and circulation time of NPs by preserving the characteristics of source cell membrane,thereby ensuring efficient drug delivery to intracranial lesions.This paper focuses on the research progress in this field,especially advantages of NPs penetrating the blood-brain barrier,immune evasion and drug delivery,as well as modified effect of different cell membrane on NPs,in order to provide help for treatment of malignant brain tumors.

关 键 词：细胞膜修饰 纳米载药系统 脑部 恶性肿瘤 血脑屏障 靶向治疗 

分 类 号：R739.41[医药卫生—肿瘤]