Nociceptors and Macrophages in Bacterial Meningitis:Partners in Crime?  

作　　者：Fang Gao Hongzhen Hu 

机构地区：[1]The Kimberly and Eric J.Waldman Department of Dermatology,Icahn School of Medicine at Mount Sinai,New York NY10029,USA [2]The Nash Family Department of Neuroscience,Icahn School of Medicine at Mount Sinai,New York NY10029,USA [3]The Mark Lebwohl Center for Neuroinfammation and Sensation,Icahn School of Medicine at Mount Sinai,New York NY10029,USA [4]Friedman Brain Institute,Icahn School of Medicine at Mount Sinai,New York NY10029,USA

出　　处：《Neuroscience Bulletin》2024年第3期418-420,共3页神经科学通报（英文版）

摘　　要：Bacterial meningitis is a serious and potentially life-threatening infection that affects the protective layers surrounding the brain and spinal cord,known as the meninges.Several types of bacteria,including Streptococcus pneumoniae,Neisseria meningitidis,and Haemophilus influenzae,can cause this condition.Certain populations,such as infants,children,immunocompromised adults,and the elderly,are particularly vulnerable to these pathogens.Symptoms of bacterial meningitis can manifest suddenly and may include high fever,severe and persistent headache,stiff neck,vomiting,sensitivity to light,and confusion or changes in mental state[1,2].Identifying these symptoms in infants can be more challenging and may lead to long-term disability or death[3].Despite the effectiveness of vaccines,it is crucial to understand how bacteria invade the brain and how our innate immune system responds to infection(Fig.1).

关 键 词：protective INFECTION suddenly 

分 类 号：R363[医药卫生—病理学]