骨髓增殖性肿瘤患者血清IL-2R、IL-8、VEGF表达情况及检测意义  

Expression and Significance of Serum IL-2R,VEGF,and IL-8 in Patients with Myeloproliferative Tumors

作　　者：马若巾[1] 张利娟 MA Ruojin;ZHANG Lijuan(Department of Hematology,the Fifth Affiliated Hospital of Zhengzhou University,Zhengzhou 450062,China;Department of Hematology and Oncology,the 988th Hospital of the Joint Logistics Support Force of the People's Liberation Army,Zhengzhou 450007,China)

机构地区：[1]郑州大学第五附属医院血液内科,河南郑州450062 [2]解放军联勤保障部队第九八八医院血液肿瘤科,河南郑州450007

出　　处：《临床医学工程》2024年第3期295-296,共2页Clinical Medicine & Engineering

摘　　要：目的 分析骨髓增殖性肿瘤患者血清白介素-2R (IL-2R)、白介素-8 (IL-8)、血管内皮生长因子(VEGF)表达情况及检测意义。方法 选取2017年10月至2022年10月收治的骨髓增殖性肿瘤患者60例(患者组),另选取健康人60例(对照组),测量其血清IL-2R、 IL-8、 VEGF水平,对比患者组治疗前后及不同类型患者间血清IL-2R、 IL-8、 VEGF水平。结果 患者组血清IL-2R、 IL-8、 VEGF高于对照组(P <0.05);真性红细胞增多症(PV)、原发性血小板增多症(ET)、原发性骨髓纤维化(PMF)患者的血清IL-2R、 IL-8水平依次递增(P <0.05)。结论 骨髓增殖性肿瘤患者血清IL-2R、 IL-8、 VEGF水平普遍高表达,治疗后明显下降,不同类型患者的血清IL-2R、 IL-8水平有显著差异,可用于诊断鉴别。Objective To analyze the expression and significance of serum interleukin-2R(IL-2R),interleukin-8(IL-8)and vascular endothelial growth factor(VEGF)in patients with myeloproliferative tumors.Methods 60 patients with myeloproliferative tumors(patient group)from October 2017 to October 2022 and 60 healthy individuals(control group)were selected,and the serum IL-2R,IL-8 and VEGF levels were detected.The serum IL-2R,IL-8 and VEGF levels before and after treatment were compared between the patient group and the control group.Results The serum IL-2R,IL-8 and VEGF levels of the patient group were higher than those of the control group(P<0.05).The serum IL-2R and IL-8 levels of polycythemia vera(PV),essential thrombocytosis(ET),and primary myelofibrosis(PMF)patients increased sequentially(P<0.05).Conclusions The serum IL-2R,IL-8,and VEGF levels are generally highly expressed in patients with myeloproliferative tumors,and significantly decrease after treatment.Serum IL-2R and IL-8 levels are significantly different among different types of patients,which can be used for diagnosis and differentiation.

关 键 词：骨髓增殖性肿瘤 白介素-2R 白介素-8 血管内皮生长因子 

分 类 号：R733.3[医药卫生—肿瘤]