舒芬太尼联合酮咯酸氨丁三醇用于直肠癌根治术后自控镇痛的效果分析  

Analysis on the Effect of Sufentanil Combined with Ketorolac Trometamol for Patient-Controlled Analgesia after Rectal Cancer Radical Surgery

作　　者：张文明 王军贞 ZHANG Wenming;WANG Junzhen(Operation Department,Pingdingshan First People's Hospital,Pingdingshan 467000,China)

机构地区：[1]平顶山市第一人民医院手术部,河南平顶山467000

出　　处：《临床医学工程》2024年第3期297-298,共2页Clinical Medicine & Engineering

摘　　要：目的探讨舒芬太尼联合酮咯酸氨丁三醇用于直肠癌根治术后自控镇痛的效果。方法选择2022年4月至2023年4月于本院行直肠癌根治术治疗的104例患者,随机分为联合组(舒芬太尼+酮咯酸氨丁三醇)与对照组(舒芬太尼)各52例。比较两组的VAS评分、血清致痛物质水平及不良反应情况。结果镇痛后6 h、12 h,联合组VAS评分低于对照组(P<0.05)。镇痛12 h时,联合组血清5-HT、P物质水平低于对照组(P<0.05)。镇痛期间两组不良反应发生率比较无统计学差异(P>0.05)。结论舒芬太尼联合酮咯酸氨丁三醇用于直肠癌根治术后自控镇痛可抑制致痛物质水平上升,镇痛效果良好,安全性高。Objective To explore the effect of sufentanil combined with ketorolac trometamol for patient-controlled analgesia after rectal cancer radical surgery.Methods 104 patients undergoing rectal cancer radical surgery in our hospital from April 2022 to April 2023 were randomly divided into combined group(52 cases,sufentanil+ketorolac trometamol)and control group(52 cases,sufentanil).The VAS score,serum pain-inducing substance level,and adverse reactions were compared between the two groups.Results After 6 hours and 12 hours of analgesia,the VAS scores of the combined group were lower than those of the control group(P<0.05).The serum 5-HT and substance P levels of combined group were lower than those of the control group(P<0.05).No statistical difference was found in the incidence of adverse reactions between the two groups during analgesia(P>0.05).Conclusions Sufentanil combined with ketorolac trometamol for patient-controlled analgesia after rectal cancer radical surgery can inhibit the increase in the pain-inducing substance level,with good analgesic effect and high safety.

关 键 词：舒芬太尼 酮铬酸氨丁三醇 术后镇痛 

分 类 号：R735.37[医药卫生—肿瘤]