儿童声带颗粒细胞瘤2例临床特征分析  

Clinical characteristics analysis of two cases of pediatric vocal cord granulosa cell tumor

作　　者：刘小红[1] 张青青 曹楠 李娜[1] 杨敏娟[1] 任晓勇[1] 罗花南[1] LIU Xiaohong;ZHANG Qingqing;CAO Nan;LI Na;YANG Minjuan;REN Xiaoyong;LUO Huanan(Department of Otolaryngology-Head and Neck Surgery,the Second Affiliated Hospital Of Xi’an Jiao Tong University,Xi’an 710004,China)

机构地区：[1]西安交通大学第二附属医院耳鼻咽喉头颈外科,西安710004

出　　处：《广西医科大学学报》2024年第3期454-457,共4页Journal of Guangxi Medical University

基　　金：陕西省科技计划资助项目(No.2023-YBSF-356);陕西省自然科学基金资助项目(No.2023-JC-YB-785)。

摘　　要：目的:分析儿童声带颗粒细胞瘤(GCT)的临床特征。方法:回顾性分析2013年1月至2023年12月西安交通大学第二附属医院收治的2例儿童声带GCT患者的临床资料。结果:病例1,女,6岁,因“发声无力3月余”入院,喉镜提示声门下弥漫性膨隆,颈部增强CT提示前联合下方低密度结节并渐进性强化;患儿在全麻下行支撑喉镜CO_(2)激光切除术,术后病理确诊GCT;术后1个月至术后2年复查,肿物无复发,术区局部瘢痕形成,但无明显黏连,声门闭合可。病例2,女,11岁,因“声嘶半年余”入院,喉镜提示前联合光滑肿物,颈部增强CT及喉部增强MRI提示前联合强化结节;患儿在全麻下行支撑喉镜CO_(2)激光切除术,术后病理确诊GCT,术后2周至术后1年复查,肿物无复发,声门下瘢痕形成,声门闭合良好。结论:儿童声带GCT常表现为发音异常,需依靠病理确诊;手术切除为其主要治疗方法,术后应密切随访。Objective:To analyze the clinical characteristics of granulosa cell tumor(GCT)in the vocal cords in children.Methods:The clinical data of 2 children with vocal cord GCT admitted to the Second Affiliated Hospital of Xi’an Jiaotong University from January 2013 to December 2023 were retrospectively analyzed.Results:Case 1,a 6-year-old female,was admitted with a chief complaint of vocal weakness for over 3 months.Under laryngoscopy,diffuse swelling was observed beneath the glottis.Enhanced CT of the neck indicated low-density nodules below the anterior commissure and progressive enhancement.The patient underwent CO_(2)laser resection under general anesthesia with a supportive laryngoscope,and the postoperative pathological diagnosis was GCT.The patient underwent follow-up examinations at 1 month and 2 years after surgery,and no recurrence of tumor was found,only local scars formed in the laryngeal cavity without obvious adhesions and with good glottal closure.Case 2,an 11-year-old female,was admitted with a chief complaint of hoarseness for over 6 months.Under laryngoscopy,a smooth mass was observed in the anterior commissure.Enhanced CT and MRI of the neck showed a nodular with enhancement in the anterior commissure.The patient underwent CO_(2)laser resection under general anesthesia with a supportive laryngoscope.The postoperative pathological diagnosis was GCT.Follow-up examinations at 2 weeks and 1 year after surgery showed no recurrence of tumor but scar formation under the glottis with good glottal closure.Conclusion:GCT of the vocal cords in children often presents with disordered voice production,which requires to be confirmed by pathological diagnosis.Surgical resection is the main treatment method,and close follow-up should be paid attention to after surgery.

关 键 词：颗粒细胞瘤 声带 儿童 手术 

分 类 号：R739.6[医药卫生—肿瘤] R767.91[医药卫生—临床医学]