靶向胰岛素样生长因子系统抗肿瘤治疗的研究进展  

Progress of Studies of Anti-Tumor Therapies Based on Targeting Insulin-like Growth Factor System

作　　者：张静[1] 潘燕[2] ZHANG Jing;PAN Yan(Key Laboratory of Molecular Biology,Inner Mongolia Medical University,Huhhot 010059,China;Department of Pharmacology,School of Basic Medicine Sciences,Peking University,Beijing 100191,China)

机构地区：[1]内蒙古医科大学分子生物学重点实验室,呼和浩特010059 [2]北京大学基础医学院药理学系,北京100191

出　　处：《中国合理用药探索》2024年第3期20-28,共9页Chinese Journal of Rational Drug Use

摘　　要：胰岛素样生长因子(IGF)系统由配体、受体、结合蛋白组成。其中,配体主要有IGF-1、IGF-2和胰岛素,通过与特定的受体结合来发挥作用;涉及受体主要有Ⅰ型IGF受体(IGF-1R)、Ⅱ型IGF受体(IGF-2R)、胰岛素受体(IR)和IGF-1R与IR的杂合受体;此外,IGF系统还包括6种高亲和力IGF结合蛋白(IGFBP-1~6)。IGF系统不仅在调节人体重要生理过程(如细胞生长、分化以及新陈代谢等)方面具有关键作用,其各组分表达水平的变化还在肿瘤的发生发展中发挥重要作用。近些年的研究显示,靶向IGF系统的各个组分或其相关信号通路有助于阻断肿瘤的发生发展并对后续肿瘤治疗产生有益作用。本文综述了IGF系统的各组分及相关信号通路在肿瘤中的作用,以及目前靶向IGF系统各组分的抗肿瘤药物研究情况,并分析了靶向IGF系统在肿瘤治疗中遇到的问题,以期为靶向IGF系统的抗肿瘤药物研究提供思路。Insulin-like growth factor(IGF)system is composed of ligands,receptors and binding proteins.The main ligands are IGF-1,IGF-2 and insulin,functioning by binding to specific receptors,including IGF type 1 receptor(IGF-1R),IGF type 2 receptor(IGF-2R),insulin receptor(IR)and the hybrid receptor of IGF-1R and IR.The IGF system also includes six high-affinity IGF binding proteins(IGFBP-1 to 6).IGF system plays a key role not only in regulation of important physiological processes(such as cell growth,differentiation and metabolism,etc.),but also in tumor development and progression through varying expression levels of components.Recent studies have shown that targeting individual components of the IGF system or its related signaling pathways is helpful in blocking the development and progression of tumor and has beneficial effects on subsequent anti-tumor therapy.This article reviews the role of the individual components of IGF system and the related signaling pathways in tumor and the current research situation of anti-tumor agents targeting the components of IGF system,and analyzes the problems encountered in anti-tumor therapy targeting the IGF system,in order to provide ideas for the study on anti-tumor agents targeting IGF system.

关 键 词：胰岛素样生长因子 靶向治疗 抗肿瘤药物 胰岛素样生长因子配体 胰岛素样生长因子受体 胰岛素样生长因子结合蛋白 

分 类 号：R730.5[医药卫生—肿瘤]