贞芪扶正胶囊辅助宫颈癌患者同步放化疗的效果  

Effect of Zhenqi Fuzheng Capsule on Concurrent Chemoradiotherapy in Patients with Cervical Cancer

作　　者：任亚娟[1] 邢雪姣 赵玲利 温馨 牛高丽 REN Yajuan;XING Xuejiao;ZHAO Lingli;WEN Xin;NIU Gaoli(Gynecology and Oncology Department Area 2,Jiaozuo Second People’s Hospital,Jiaozuo 454000,Henan,China)

机构地区：[1]焦作市第二人民医院妇瘤科二区,河南焦作454000

出　　处：《中国药物滥用防治杂志》2024年第2期328-332,共5页Chinese Journal of Drug Abuse Prevention and Treatment

摘　　要：目的:探究贞芪扶正胶囊治疗宫颈癌同步放化疗患者的临床疗效。方法:选取本院2018年6月—2022年8月收治的80例宫颈癌患者,按随机数字表法分为对照组、联合组,各40例。对照组给予放化疗治疗,联合组给予贞芪扶正胶囊+放化疗治疗。比较两组近期疗效、免疫功能[CD3^(+)、CD4^(+)、调节性T(Treg)细胞、自然杀伤(NK)细胞]、炎症反应因子[白介素-4(IL-4)、肿瘤坏死因子-α(TNF-α)、超敏C反应蛋白(CRP)]、Piper疲乏修订量表(PFS-R)、卡氏功能状态(KPS)评分及毒副反应。结果:联合组客观有效率为62.50%、疾病控制率为87.50%,高于对照组的40.00%、67.50%(P<0.05);治疗后,联合组CD3^(+)、CD4^(+)、Treg细胞、NK细胞水平均高于对照组,TNF-α、IL-4、CRP水平均低于对照组(P<0.05);联合组PFS-R评分低于对照组,KPS评分高于对照组(P<0.05);联合组骨髓抑制、胃肠道反应、肝肾异常、贫血发生率均低于对照组(P<0.05)。结论:贞芪扶正胶囊能提高宫颈癌同步放化疗患者免疫功能、生活质量,并改善癌因性疲乏、降低毒副反应。Objective:To explore the clinical efficacy of Zhenqi Fuzheng capsule in the treatment of cervical cancer patients with concurrent chemoradiotherapy.Methods:A total of 80 patients with cervical cancer admitted to our hospital from June 2018 to August 2022 were selected and divided into control group and combined group according to the random number table method,with 40 cases in each group.The control group was treated with radiotherapy and chemotherapy,and the combined group was treated with Zhenqi Fuzheng capsule+radiotherapy and chemotherapy.The short-term efficacy,immune function[CD3^(+),CD4^(+),regulatory T(Treg)cells,natural killer(NK)cells],inflammatory response factors[interleukin-4(IL-4),tumor necrosis factor-α(TNF-α),high-sensitivity C-reactive protein(CRP)],Piper fatigue revised scale(PFS-R),Karnofsky performance status(KPS)score and toxic and side effects were compared between the two groups.Results:The objective effective rate of the combined group was 62.50%,and the disease control rate was 87.50%,which was higher than 40.00%and 67.50%of the control group(P<0.05).After treatment,the levels of CD3^(+),CD4^(+),Treg cells and NK cells in the combined group were higher than those in the control group,and the levels of TNF-α,IL-4 and CRP were lower than those in the control group(P<0.05).The PFS-R score of the combined group was lower than that of the control group,and the KPS score was higher than that of the control group(P<0.05).The incidence of bone marrow suppression,gastrointestinal reactions,liver and kidney abnormalities,and anemia in the combined group were lower than those in the control group(P<0.05).Conclusion:Zhenqi Fuzheng Capsule can improve the immune function and quality of life of patients with cervical cancer undergoing concurrent chemoradiotherapy,and improve cancer-related fatigue and reduce toxicity.

关 键 词：贞芪扶正胶囊 宫颈癌 放化疗 免疫功能 疲倦 骨髓抑制 

分 类 号：R737.33[医药卫生—肿瘤] R969[医药卫生—临床医学]