肿瘤微环境中细胞代谢相互作用的研究进展  

Advances in Research on Cell Metabolic Interactions in the Tumor Microenvironment

作　　者：吴朋飞 杨智 李青晏 王德年 WU Pengfei;YANG Zhi;LI Qingyan;WANG Denian(Precision Medicine Research Center,Precision Medicine Key Laboratory of Sichuan Province,Institute of Respiratory and Comorbidity,West China Hospital,Sichuan University,Chengdu 610041,China;Institute of Respiratory Health,Frontiers Science Center for Disease-Related Molecular Network,Institute of Respiratory and Comorbidity,West China Hospital,Sichuan University,Chengdu 610041,China;Department of Nephrology,West China Hospital,Sichuan University,Chengdu 610041,China)

机构地区：[1]四川大学华西医院呼吸与共病研究院精准医学研究中心/精准医学四川省重点实验室,成都610041 [2]四川大学华西医院呼吸与共病研究院呼吸健康研究所,成都610041 [3]四川大学华西医院肾脏内科,成都610041

出　　处：《四川大学学报（医学版）》2024年第2期482-489,共8页Journal of Sichuan University(Medical Sciences)

基　　金：国家自然科学基金(No.82102301);四川省自然科学基金(No.2021YJ0418)资助。

摘　　要：代谢重编程对肿瘤的发生和发展至关重要。肿瘤细胞的代谢及增殖受到细胞内在因素和肿瘤微环境(tumor microenvironment, TME)中代谢物的共同调节。TME中的代谢主要受到3个层面的调节:肿瘤代谢本身内在因素的调节;肿瘤细胞与T细胞、髓系细胞、基质细胞之间代谢产物的相互影响;肿瘤细胞在组织空间中的代谢异质性。本文就肿瘤细胞不同的代谢调节模式进行了简要概述,并深入剖析了肿瘤细胞与TME中其他细胞的代谢相互影响,以及各类细胞的代谢特征和功能情况。这进一步为肿瘤的精准治疗提供了理论基础和新的思路。Metabolic reprogramming plays a critical role in tumorigenesis and tumor progression.The metabolism and the proliferation of tumors are regulated by both intrinsic factors within the tumor and the availability of metabolites in the tumor microenvironment(TME).The metabolic niche within the TME is primarily orchestrated at 3 levels:1)the regulation of tumor metabolism by factors intrinsic to the tumors,2)the interaction between tumor cells and T cells,macrophages,and stromal cells,and 3)the metabolic heterogeneity of tumor cells within the tissue space.Herein,we provided a concise overview of the various metabolic regulatory modes observed in tumor cells.Additionally,we extensively analyzed the interaction between tumor cells and other cells within the TME,as well as the metabolic characteristics and functions of different types of cells.Ultimately,this review provides a theoretical basis and novel insights for the precision treatment of tumors.

关 键 词：代谢重编程 肿瘤微环境 代谢异质性 糖酵解 代谢治疗 综述 

分 类 号：R730.2[医药卫生—肿瘤]