唾液外泌体miRNAs在头颈部鳞状细胞癌中的研究进展  

Advances in salivary exosomal miRNAs in head and neck squamous carcinoma

作　　者：何锦怡 杨柳[2] HE Jinyi;YANG Liu(West China School of Clinical Medicine,Sichuan University,Chengdu,610041,China;Department of Otolaryngology Head&Neck Surgery,West China Hospital,Sichuan University)

机构地区：[1]四川大学华西临床医学院,成都610041 [2]四川大学华西医院耳鼻咽喉头颈外科

出　　处：《临床耳鼻咽喉头颈外科杂志》2024年第3期261-266,共6页Journal of Clinical Otorhinolaryngology Head And Neck Surgery

摘　　要：唾液外泌体是指存在于唾液中的直径为30~150 nm的细胞外囊泡,在细胞之间的物质交换和信号转导方面发挥重要作用,能将其携带的脂质、蛋白质、核酸传递至受体细胞,调节受体细胞的生理、病理过程。miRNA作为外泌体中重要的“货物”被转运至受体细胞,调控受体细胞信号通路,从而对疾病的进展起着调节的作用。随着近年来技术手段的发展,大量研究揭示了唾液外泌体miRNA在头颈鳞癌的发生发展中发挥重要作用以及唾液外泌体miRNA在头颈鳞癌的诊断与治疗作用。本文综述了唾液外泌体miRNA在头颈鳞癌中的发生、治疗和预后,并讨论唾液外泌体miRNA作为生物标志物在头颈鳞癌诊断中的潜在前景和重要意义。Salivary exosomes are extracellular vesicles of 30-150 nm in diameter that exist in saliva and play an important role in substance exchange and signal transduction between cells,delivering the lipids,proteins and nucleic acids they carry to the recipient cells and regulating the physiological and pathological processes of the recipient cells.miRNA,as an important"cargo"in exosomes,is transported to the recipient cells and regulates the signaling pathways of the recipient cells,thus playing a regulatory role in disease progression.The miRNAs are transported to the recipient cells and regulate the signaling pathways of the recipient cells,thus playing a regulatory role in the progression of diseases.With the development of technological tools this year,numerous studies have revealed the important role of salivary exosomal miRNAs in the development of head and neck squamous carcinoma and the role of salivary exosomal miRNAs in the diagnosis and treatment of head and neck squamous carcinoma.This paper reviews the occurrence,treatment and prognosis of salivary exosomal miRNA in head and neck squamous carcinoma,and discusses the potential prospects and importance of salivary exosomal miRNA as a biomarker in the diagnosis of head and neck squamous carcinoma.

关 键 词：细胞外囊泡 唾液外泌体 生物标志物 头颈部鳞状细胞肿瘤 

分 类 号：R739.91[医药卫生—肿瘤]