膳食炎症指数与血清炎症标志物和血脂异常的相关性研究  

The Association of Dietary Inflammatory Index with Serum Inflammatory Markers and Dyslipidemia

作　　者：张亚娣 李小霞[1] 尹婷 杨婵[3] 张毓洪[1,2] 赵燚 ZHANG Yadi;LI Xiaoxia;YIN Ting;YANG Chan;ZHANG Yuhong;ZHAO Yi(School of Public Health,Ningxia Medical University,Yinchuan 750004,China;Ningxia Key Laboratory of Environmental Factors and Chronic Disease Control,Yinchuan 750004,China;School of Nursing,Ningxia Medical University,Yinchuan 750004,China)

机构地区：[1]宁夏医科大学公共卫生学院,银川750004 [2]宁夏环境因素与慢性病控制重点实验室,银川750004 [3]宁夏医科大学护理学院,银川750004

出　　处：《宁夏医科大学学报》2024年第2期176-181,共6页Journal of Ningxia Medical University

基　　金：宁夏回族自治区重点研发计划项目(2021BEG02026);宁夏自然科学基金项目(2020AAC03188)。

摘　　要：目的探讨能量调整的膳食炎症指数(energy-adjusted DII,E-DII)与炎性因子和血脂异常之间的关系。方法数据来自宁夏自然人群队列,按照成组匹配的病例对照研究纳入病例组(血脂异常者)245例和对照组247例。膳食调查采用食物频率法并计算E-DII。利用Spearman相关和二元Logistic回归模型分别分析E-DII与炎性因子和血脂异常的关系。结果病例组的血脂指标(TC、TG、LDL-C)和炎性因子(IL-2、IL-6、TNF-α)的平均值高于对照组,IL-18低于对照组(P均<0.05)。E-DII的范围为-2.86~3.81,其平均值在两组间差异无统计学意义(P>0.05)。将E-DII按三分位数分组,在中性组IL-6与E-DII呈正相关(r=0.162,P=0.038),在促炎倾向组E-DII与IL-18呈负相关(r=-0.188,P=0.016)。在Logistics回归模型中,经调整混杂因素前后,以及在糖尿病和非糖尿患者群亚组分析中,未发现E-DII和血脂异常的关联,经趋势性检验差异无统计学意义(P均>0.05)。结论E-DII与IL-6和IL-18相关,尚未发现其与血脂异常的关联。Objective This study aimed to explore the association of energy-adjusted DII(E-DII)with inflammatory factors and dyslipidemia.Methods Data came from Ningxia natural population cohort.According to the matched case-control design,245 subjects with dyslipidemia and 247 control subjects were included. Dietary surveys used the food frequency method and the E-DII was calculated. Spearman correlation analysis and binary Logistic regression models were used to analyze the relationship between E-DII and inflammatory factors and dyslipidemia,respectively. Results The mean values of blood lipid indicators(TC,TG,LDL-C) and inflammatory factors(IL-2,IL-6,TNF-α) in the case group were higher than those in the control group,while IL-18 was lower in the case group(P all<0.05). The range of E-DII was from -2.86 to 3.81,and the mean value between the two groups showed no significant difference(P>0.05). When E-DII was divided into three quartiles,there was a positive correlation between IL-6 and E-DII in the neutral group(r=0.162,P=0.038),and a negative correlation between E-DII and IL-18 in the pro-inflammatory tendency group(r=-0.188,P=0.016). In the Logistic regression model,after adjusting for confounding factors and in subgroup analyses of diabetic and non-diabetic populations,no association was found between E-DII and dyslipidemia,which was tested by trend analysis(P all>0.05). Conclusion E-DII is related to IL-6 and IL-18,but not to dyslipidemia.

关 键 词：能量调整的膳食炎症指数 血脂异常 炎症标志物 病例对照研究 

分 类 号：R151.4[医药卫生—营养与食品卫生学]