Understanding wound healing in obesity  

作　　者：Asha Cotterell Michelle Griffin Mauricio A Downer Jennifer B Parker Derrick Wan Michael T Longaker 

机构地区：[1]Division of Plastic and Reconstructive Surgery,Stanford University,Palo Alto,CA 94301,United States [2]Stanford University School of Medicine,Stanford University School of Medicine,Palo Alto,CA 94301,United States [3]Department of Surgery,Stanford University School of Medicine,Hagey Laboratory for Pediatric Regenerative Medicine,Palo Alto,CA 94301,United States

出　　处：《World Journal of Experimental Medicine》2024年第1期22-32,共11页世界实验医学杂志

摘　　要：Obesity has become more prevalent in the global population.It is associated with the development of several diseases including diabetes mellitus,coronary heart disease,and metabolic syndrome.There are a multitude of factors impacted by obesity that may contribute to poor wound healing outcomes.With millions worldwide classified as obese,it is imperative to understand wound healing in these patients.Despite advances in the understanding of wound healing in both healthy and diabetic populations,much is unknown about wound healing in obese patients.This review examines the impact of obesity on wound healing and several animal models that may be used to broaden our understanding in this area.As a growing portion of the population identifies as obese,understanding the underlying mechanisms and how to overcome poor wound healing is of the utmost importance.

关 键 词：OBESITY Wound healing ADIPOKINES Tissue fibrosis Diabetes Preclinical animal models Hypertrophic skin scarring Wound tension Metabolic syndrome 

分 类 号：R58[医药卫生—内分泌]