Pre-operative enhanced magnetic resonance imaging combined with clinical features predict early recurrence of hepatocellular carcinoma after radical resection  

作　　者：Jian-Ping Chen Ri-Hui Yang Tian-Hui Zhang Li-An Liao Yu-Ting Guan Hai-Yang Dai 

机构地区：[1]Department of Intervention,Meizhou People’s Hospital,Meizhou 514031,Guangdong Province,China [2]Department of Medical Imaging,Meizhou People’s Hospital,Meizhou 514031,Guangdong Province,China [3]Department of Medical Imaging,Huizhou Municipal Central Hospital,Huizhou 516001,Guangdong Province,China

出　　处：《World Journal of Gastrointestinal Oncology》2024年第4期1192-1203,共12页世界胃肠肿瘤学杂志（英文版）（电子版）

基　　金：This study was reviewed and approved by the Meizhou People’s Hospital Institutional Review Board(Approval No.2022-C-36).

摘　　要：BACKGROUND Indentifying predictive factors for postoperative recurrence of hepatocellular carcinoma(HCC)has great significance for patient prognosis.AIM To explore the value of gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid(Gd-EOB-DTPA)enhanced magnetic resonance imaging(MRI)combined with clinical features in predicting early recurrence of HCC after resection.METHODS A total of 161 patients with pathologically confirmed HCC were enrolled.The patients were divided into early recurrence and non-early recurrence group based on the follow-up results.The clinical,laboratory,pathological results and Gd-EOB-DTPA enhanced MRI imaging features were analyzed.RESULTS Of 161 patients,73 had early recurrence and 88 were had non-early recurrence.Univariate analysis showed that patient age,gender,serum alpha-fetoprotein level,the Barcelona Clinic Liver Cancer stage,China liver cancer(CNLC)stage,microvascular invasion(MVI),pathological satellite focus,tumor size,tumor number,tumor boundary,tumor capsule,intratumoral necrosis,portal vein tumor thrombus,large vessel invasion,nonperipheral washout,peritumoral enhancement,hepatobiliary phase(HBP)/tumor signal intensity(SI)/peritumoral SI,HBP peritumoral low signal and peritumoral delay enhancement were significantly associated with early recurrence of HCC after operation.Multivariate logistic regression analysis showed that patient age,MVI,CNLC stage,tumor boundary and large vessel invasion were independent predictive factors.External data validation indicated that the area under the curve of the combined predictors was 0.861,suggesting that multivariate logistic regression was a reasonable predictive model for early recurrence of HCC.CONCLUSION Gd-EOB-DTPA enhanced MRI combined with clinical features would help predicting the early recurrence of HCC after operation.

关 键 词：Hepatocellular carcinoma Enhanced magnetic resonance imaging Microvascular invasion Hepatobiliary phase RECURRENCE 

分 类 号：R735.7[医药卫生—肿瘤]