Mucinous neoplasm of the appendix:A case report and review of literature  

作　　者：Hao-Cheng Chang Jung-Cheng Kang Ta-Wei Pu Ruei-Yu Su Chao-Yang Chen Je-Ming Hu 

机构地区：[1]Department of Surgery,Tri-Service General Hospital,Taipei 114,Taiwan,China [2]Division of Colon and Rectal Surgery,Department of Surgery,Taiwan,China Adventist Hospital,Taipei 105,Taiwan,China [3]Division of Colon and Rectal Surgery,Department of Surgery,Tri-Service General Hospital Songshan Branch,National Defense Medical Center,Taipei 105,Taiwan,China [4]Division of Colon and Rectal Surgery,Department of Surgery,Tri-Service General Hospital,National Defense Medical Center,Taipei 114,Taiwan,China [5]Department of Pathology,Tri-Service General Hospital,National Defense Medical Center,Taipei 105,Taiwan,China [6]Department of Pathology and Laboratory Medicine,Taoyuan Armed Forces General Hospital,Taoyuan 325,Taiwan,China

出　　处：《World Journal of Gastrointestinal Surgery》2024年第3期944-954,共11页世界胃肠外科杂志（英文版）（电子版）

摘　　要：BACKGROUND Appendiceal mucinous neoplasms(AMNs),although not classified as rare,are relatively uncommon tumors most often discovered incidentally during colorectal surgery.Accurate identification of AMNs is difficult due to non-specific sym-ptoms,overlapping tumor markers with other conditions,and the potential for misdiagnosis.This underscores the urgent need for precision in diagnosis to pre-vent severe complications.CASE SUMMARY This case report describes the unexpected discovery and treatment of a low-grade AMN(LAMN)in a 74-year-old man undergoing laparoscopic hemicolectomy for transverse colon adenocarcinoma(AC).Preoperatively,non-specific gastroin-testinal symptoms and elevated tumor markers masked the presence of AMN.The tumor,presumed to be an AMN peritoneal cyst intraoperatively,was con-firmed as LAMN through histopathological examination.The neoplasm exhibited mucin accumulation and a distinct immunohistochemical profile:Positive for Ho-meobox protein CDX-2,Cytokeratin 20,special AT-rich sequence-binding protein 2,and Mucin 2 but negative for cytokeratin 7 and Paired box gene 8.This profile aids in distinguishing appendiceal and ovarian mucinous tumors.Postoperative recovery was uncomplicated,and the patient initiated adjuvant chemotherapy for the colon AC.CONCLUSION This case highlights the diagnostic complexity of AMNs,emphasizing the need for vigilant identification to avert potential complications,such as pseudomyxoma peritonei.

关 键 词：Adenocarcinoma Appendiceal neoplasms Low-grade appendiceal mucinous neoplasm Peritoneal neoplasms Pseudomyxoma peritonei Case report 

分 类 号：R735.37[医药卫生—肿瘤]