Associations of PNPLA3 and LEP genetic polymorphisms with metabolic-associated fatty liver disease in Thai people living with human immunodeficiency virus  

作　　者：Kanuengnit Choochuay Punna Kunhapan Apichaya Puangpetch Sissades Tongsima Pornpen Srisawasdi Abhasnee Sobhonslidsuk Somnuek Sungkanuparph Mohitosh Biswas Chonlaphat Sukasem 

机构地区：[1]Program in Translational Medicine,Faculty of Medicine Ramathibodi Hospital,Mahidol University,Bangkok 10400,Thailand [2]School of Pharmacy,Walailak University,Nakhon Si Thammarat 80161,Thailand [3]Laboratory for Pharmacogenomics,Division of Pharmacogenomics and Personalized Medicine,Somdech Phra Debaratana Medical Center,Department of Pathology,Faculty of Medicine Ramathibodi Hospital,Mahidol University,Bangkok 10400,Thailand [4]Department of Medical Sciences,Ministry of Public Health,Nonthaburi 11000,Thailand [5]National Biobank of Thailand,National Center for Genetic Engineering and Biotechnology,Pathum Thani 12120,Thailand [6]Division of Clinical Chemistry,Department of Pathology,Faculty of Medicine Ramathibodi Hospital,Mahidol University,Bangkok 10400,Thailand [7]Division of Gastroenterology and Hepatology,Department of Medicine,Faculty of Medicine Ramathibodi Hospital,Mahidol University,Bangkok 10400,Thailand [8]Chakri Naruebodindra Medical Institute,Faculty of Medicine Ramathibodi Hospital,Mahidol University,Samut Prakan 10540,Thailand [9]Department of Pharmacy,University of Rajshahi,Rajshahi 6205,Bangladesh [10]Pharmacogenomics Clinic,Bumrungrad Genomic Medicine Institute,Bumrungrad International Hospital,Bangkok 10110,Thailand [11]Research and Development Laboratory,Bumrungrad International Hospital,Bangkok 10110,Thailand [12]MRC Centre for Drug Safety Science,Department of Pharmacology and Therapeutics,Institute of Systems,Molecular and Integrative Biology,University of Liverpool Liverpool L693GL,United Kingdom [13]Faculty of Pharmaceutical Sciences,Burapha University,Chonburi 20131,Thailand

出　　处：《World Journal of Hepatology》2024年第3期366-378,共13页世界肝病学杂志（英文版）（电子版）

基　　金：Supported by the Faculty of Medicine,Ramathibodi Hospital,Mahidol University。

摘　　要：BACKGROUND The prevalence of metabolic-associated fatty liver disease(MAFLD)is a growing public health issue in people living with human immunodeficiency virus(PLWH).However,the pathophysiology of MAFLD is still unknown,and the role of genetic variables is only now becoming evident.AIM To evaluate the associations of gene-polymorphism-related MAFLD in PLWH.METHODS The study employed transient elastography with a controlled attenuation parameter≥248 dB/m to identify MAFLD in patients from a Super Tertiary Hospital in central Thailand.Candidate single-nucleotide polymorphisms(SNPs)were genotyped using TaqMan®MGB probe 5'nuclease assays for seven MAFLD-related genes.Statistical analyses included SNP frequency analysis,Fisher's Exact and Chi-square tests,odds ratio calculations,and multivariable logistic regression.RESULTS The G-allele carriers of PNPLA3(rs738409)exhibited a two-fold rise in MAFLD,increasing by 2.5 times in MAFLD with human immunodeficiency virus infection.The clinical features and genetic patterns imply that LEP rs7799039 A-allele carriers had a nine times(P=0.001)more significant chance of developing aberrant triglyceride among PLWH.CONCLUSION The current study shows an association between PNPLA3 rs738409 and LEP rs7799039 with MAFLD in PLWH.

关 键 词：PNPLA3 LEP Metabolic-associated fatty liver disease People living with HIV THAI 

分 类 号：R575.5[医药卫生—消化系统]