Growth differentiation factor-15 serum concentrations reflect disease severity and anemia in patients with inflammatory bowel disease  

作　　者：Ante Tonkic Marko Kumric Ivna Akrapovic Olic Doris Rusic Piero Marin Zivkovic Daniela Supe Domic Zeljko Sundov Ivan Males Josko Bozic 

机构地区：[1]Biology of Neoplasms,University of Split School of Medicine,Split 21000,Croatia [2]Department of Pathophysiology,University of Split School of Medicine,Split 21000,Croatia [3]Department of Gastroenterology,University Hospital of Split,Split 21000,Croatia [4]Department of Pharmacy,University of Split School of Medicine,Split 21000,Croatia [5]Department of Medical Laboratory Diagnostics,University Hospital of Split,Split 21000,Croatia [6]Department of Health Studies,University of Split,Split 21000,Croatia [7]Department of Internal Medicine,University of Split School of Medicine,Split 21000,Croatia [8]Department of Surgery,University Hospital of Split,Split 21000,Croatia

出　　处：《World Journal of Gastroenterology》2024年第13期1899-1910,共12页世界胃肠病学杂志（英文版）

摘　　要：BACKGROUND Population of patients with inflammatory bowel disease(IBD)is burdened by various extraintestinal manifestations which substantially contribute to greater morbidity and mortality.Growth-differentiation factor-15(GDF-15)is often overexpressed under stress conditions,such as inflammation,malignancies,heart failure,myocardial ischemia,and many others.AIM To explore the association between GDF-15 and IBD as serum concentrations of GDF-15 were shown to be an independent predictor of poor outcomes in multiple diseases.An additional aim was to determine possible associations between GDF-15 and multiple clinical,anthropometric and laboratory parameters in patients with IBD.METHODS This cross-sectional study included 90 adult patients diagnosed with IBD,encompassing both Crohn’s disease(CD)and ulcerative colitis(UC),and 67 healthy age-and sex-matched controls.All patients underwent an extensive workup,including colonoscopy with subsequent histopathological analysis.Disease activity was assessed by two independent gastroenterology consultants specialized in IBD,employing well-established clinical and endoscopic scoring systems.GDF-15 serum concentrations were determined following an overnight fasting,using electrochemiluminescence immunoassay.RESULTS In patients with IBD,serum GDF-15 concentrations were significantly higher in comparison to the healthy controls[800(512-1154)pg/mL vs 412(407-424)pg/mL,P<0.001],whereas no difference in GDF-15 was found between patients with CD and UC[807(554-1451)pg/mL vs 790(509-956)pg/mL,P=0.324].Moreover,multiple linear regression analysis showed that GDF-15 levels predict CD and UC severity independent of age,sex,and C-reactive protein levels(P=0.016 and P=0.049,respectively).Finally,an association between GDF-15 and indices of anemia was established.Specifically,negative correlations were found between GDF-15 and serum iron levels(r=-0.248,P=0.021),as well as GDF-15 and hemoglobin(r=-0.351,P=0.021).Accordingly,in comparison to IBD patients with normal hemoglobin levels,GDF-

关 键 词：Inflammatory bowel disease Crohn’s disease Ulcerative colitis Growth-differentiation factor-15 ANEMIA Extraintestinal manifestations 

分 类 号：R574[医药卫生—消化系统]