Pulmonary alveolar proteinosis induced by X-linked agammaglobulinemia:A case report  

作　　者：Ting Zhang Ming Li Li Tan Xin Li 

机构地区：[1]Department of Respiratory Medicine,Kunming Children´s Hospital,Kunming 650228,Yunnan Province,China [2]Department of Emergency,Kunming Children's Hospital,Kunming 650228,Yunnan Province,China

出　　处：《World Journal of Clinical Cases》2024年第9期1644-1648,共5页世界临床病例杂志

基　　金：Supported by Sanitation Research Project of Kunming Municipal Health Commission,No.2020-06-01-119.

摘　　要：BACKGROUND Pulmonary alveolar proteinosis(PAP)and X-linked agammaglobulinemia(XLA)are rare diseases in children.Many theories infer that immunodeficiency can induce PAP,but these reports are almost all review articles,and there is little clinical evidence.We report the case of a child with both PAP and XLA.CASE SUMMARY A 4-month-old boy sought medical treatment due to coughing and difficulty in breathing for>2 wk.He had been hospitalized multiple times due to respiratory infections and diarrhea.Chest computed tomography and alveolar lavage fluid showed typical PAP-related manifestations.Genetic testing confirmed that the boy also had XLA.Following total lung alveolar lavage and intravenous immunoglobulin replacement therapy,the boy recovered and was discharged.During the follow-up period,the number of respiratory infections was significantly reduced,and PAP did not recur.CONCLUSION XLA can induce PAP and improving immune function contributes to the prognosis of children with this type of PAP.

关 键 词：Pulmonary alveolar proteinosis X-linked agammaglobulinemia CHILDREN IMMUNODEFICIENCY Alveolar lavage Case report 

分 类 号：R737.9[医药卫生—肿瘤]