肿瘤相关巨噬细胞:调节肿瘤微环境的新靶点  

Tumor-associated Macrophage:Emerging Targets for Modulating the Tumor Microenvironment

作　　者：周银雪 任敦强[1] 毕焕焕 易冰倩 张彩[1] 王红梅[1] 孙家兴[1] Yinxue ZHOU;Dunqiang REN;Huanhuan BI;Bingqian YI;Cai ZHANG;Hongmei WANG;Jiaxing SUN(Department of Respiratory and Critical Care Medicine,The Affiliated Hospital of Qingdao University,Qingdao 266000,China;School of Medicine,Qingdao University,Qingdao 266000,China)

机构地区：[1]青岛大学附属医院呼吸与危重症医学科,青岛266000 [2]青岛大学医学部,青岛266000

出　　处：《中国肺癌杂志》2024年第3期231-240,共10页Chinese Journal of Lung Cancer

摘　　要：肿瘤相关巨噬细胞(tumor-associated macrophage,TAM)在肺癌免疫微环境中扮演着重要的角色。它们通过自身的表型和吞噬功能的变化,在肺癌的发生和进展中发挥作用,通过促进肺癌免疫抑制型微环境的形成和肿瘤异常血管的生长加速肺癌的侵袭和扩散。巨噬细胞在应对不同刺激时,可以极化为具有不同功能和特征的亚型,分为抗肿瘤M1型和促肿瘤的M2型。在肿瘤组织中,TAM通常极化为交替活化型的M2表型,表现出对肿瘤免疫的抑制作用。本文综述了抗血管生成药物在调节TAM表型方面的作用,它们可以通过将M2型TAM重编程为M1型来发挥抗肿瘤作用。同时,TAM的功能改变在抗血管生成治疗和免疫治疗策略中也起到重要作用。研究证实,TAM通过极化及功能改变可能成为调节肿瘤微环境的新靶点,开辟肺癌治疗的新途径。Tumor-associated macrophage(TAM)play a crucial role in the immune microenvironment of lung can-cer.Through changes in their phenotype and phagocytic functions,TAM contribute to the initiation and progression of lung cancer.By promoting the formation of an immune-suppressive microenvironment and accelerating the growth of abnormal tumor vasculature,TAM facilitate the invasion and metastasis of lung cancer.Macrophages can polarize into different subtypes with distinct functions and characteristics in response to various stimuli,categorized as anti-tumor M1 and pro-tumor M2 types.In tumor tissues,TAM typically polarize into the alternatively activated M2 phenotype,exhibiting inhibitory effects on tumor immunity.This article reviews the role of anti-angiogenic drugs in modulating TAM phenotypes,highlighting their po-tential to reprogram M2-type TAM into an anti-tumor M1 phenotype.Additionally,the functional alterations of TAM play a significant role in anti-angiogenic therapy and immunotherapy strategies.In summary,the regulation of TAM polarization and function opens up new avenues for lung cancer treatment and may serve as a novel target for modulating the immune microen-vironment of tumors.

关 键 词：肿瘤相关巨噬细胞 极化 抗血管生成治疗 肺肿瘤 

分 类 号：R734.2[医药卫生—肿瘤]