基质金属蛋白酶-12、13在口腔鳞状细胞癌患者血清及唾液中的表达及意义  

Expression and significance of matrix metalloproteinase-12 and 13 in serum and saliva of patients with oral squamous cell carcinom

作　　者：周亚 徐静[1] Zhou Ya;Xu Jing(Stomatology Clinic,The First Affiliated Hospital of Zhengzhou University,Zhengzhou 450000,China)

机构地区：[1]郑州大学第一附属医院口腔门诊,郑州450000

出　　处：《河南外科学杂志》2024年第2期7-11,共5页Henan Journal of Surgery

摘　　要：目的探讨基质金属蛋白酶-12、13(MMP-12、13)在口腔鳞状细胞癌(OSCC)患者血清及唾液中的表达及意义。方法收集72例OSCC患者(OSCC组)、50例癌前病变患者(癌前病变组)和50例健康体检者(对照组)的静脉血和唾液,检测并比较3组患者的血清及唾液MMP-12、13水平,采用受试者工作特征曲线(ROC)分析MMP-12、13对OSCC的诊断价值并分析其与OSCC患者临床病理特征的关系。结果OSCC组及癌前病变组血清及唾液MMP-12、13水平均明显高于对照组(P<0.05);OSCC组血清及唾液MMP-12水平明显高于癌前病变组,OSCC组唾液MMP-13水平明显高于癌前病变组(P<0.05)。ROC分析结果显示,以对照组为参照,血清及唾液MMP-12诊断OSCC的曲线下面积(AUC)分别为0.964和0.932,血清及唾液MMP-13诊断OSCC的AUC分别为0.968和0.947;以癌前病变组为参照,血清及唾液MMP-12诊断OSCC的AUC分别为0.819和0.787,血清及唾液MMP-13诊断OSCC的AUC分别为0.588和0.597。血清及唾液MMP-12、13水平与OSCC患者肿瘤直径、TNM分期及淋巴结转移有关(P<0.05)。结论OSCC患者血清及唾液MMP-12、13水平均明显升高,且对OSCC具有一定的诊断价值。Objective To investigate the expression and significance of matrix metalloproteinase-12 and 13(MMP-12 and 13)in the serum and saliva of patients with oral squamous cell carcinoma(OSCC).Methods Venous blood and saliva samples were collected from 72 patients with OSCC(OSCC group)and 50 patients with precancerous lesions(precancerous lesion group)and 50 healthy subjects(control group),the levels of MMP-12 and 13 in serum and saliva were detected and compared among the three groups.The receiver operating characteristic(ROC)curve was used to analyze the diagnostic value of MMP-12 and MMP-13 in OSCC,and the relationship between MMP-12 and MMP-13 and the clinicopathological characteristics of OSCC patients was analyzed.Results The levels of serum and saliva MMP-12 and MMP-13 in OSCC and precancerous lesions were significantly higher than those of the control group(P<0.05);The levels of MMP-12 in serum and saliva of OSCC patients were significantly higher than those of precancerous lesions,and the level of MMP-13 in the saliva of OSCC patients was significantly higher than that of precancerous lesions(P<0.05).ROC analysis showed that the area under the curve(AUC)of serum and saliva MMP-12 in the diagnosis of OSCC was 0.964 and 0.932,respectively,and that of serum and saliva MMP-13 in the diagnosis of OSCC was 0.968 and 0.947,respectively.Compared with the precancerous lesion group,the AUC of serum and saliva MMP-12 in the diagnosis of OSCC was 0.819 and 0.787,respectively.The AUC of serum and saliva MMP-13 in the diagnosis of OSCC was 0.588 and 0.597,respectively.The levels of serum and saliva MMP-12,13 were related to tumor diameter,TNM stage,and lymph node metastasis in patients with OSCC(P<0.05);Conclusion The levels of MMP-12 and MMP-13 in serum and saliva of OSCC patients are significantly increased,and they have certain diagnostic value for OSCC.

关 键 词：血清 唾液 基质金属蛋白酶-12、13 口腔鳞状细胞癌 

分 类 号：R781.4[医药卫生—口腔医学]