益生菌联合复方聚乙二醇散+乳果糖在慢性便秘患者肠道准备中的应用价值  

The application value of probiotics combined with compound polyethylene glycol powder+lactulose in bowel preparation of patients with chronic constipation

作　　者：兰强芳 周燕[1] 邵伟[1] LAN Qiangfang;ZHOU Yan;SHAO Wei(Department of Gastroenterology,Zhejiang University School of Medicine Affiliated Sir Run Run Shaw Hospital Branch(Zhejiang Putuo Hospital),Zhoushan 316100,Zhejiang Province,China)

机构地区：[1]浙江大学医学院附属邵逸夫医院分院(浙江普陀医院)消化内科,浙江舟山316100

出　　处：《中国药师》2024年第3期463-469,共7页China Pharmacist

基　　金：舟山市科技计划项目(2018C11045)。

摘　　要：目的 探究益生菌联合复方聚乙二醇散+乳果糖在慢性便秘(CC)患者结肠镜检查肠道准备中的应用价值。方法 纳入2022年6月至2023年12月浙江普陀医院消化内科拟行结肠镜检查的CC患者。采用随机数字表法,将患者随机分为益生菌组(益生菌联合复方聚乙二醇散+乳果糖)和对照组(复方聚乙二醇散+乳果糖)。评估并比较益生菌组和对照组肠道清洁度[波士顿肠道准备量表(BBPS评分)和肠道清洁有效率]、肠道气泡评分、结肠镜检查质量指标(息肉检出率、腺瘤检出率、结肠镜操作时间和结肠镜完成率)、耐受性(耐受率和再次接受检查率)和不良反应发生率。结果 研究共纳入120例CC患者,每组各60例,益生菌组和对照组结肠镜检查完成率均为100.00%。益生菌组左半结肠评分、中段结肠评分、右半结肠评分、BBPS评分、肠道清洁有效率、肠道气泡评分满意度均显著高于对照组(P <0.05);两组息肉检出率、腺瘤检出率差异无统计学意义(P> 0.05)。与对照组相比,益生菌组结肠镜操作时间短,耐受率和再次接受检查率高,不良反应发生率低(P <0.05)。结论 益生菌可提高复方聚乙二醇散+乳果糖在CC患者结肠镜检查肠道准备中的效果和安全性。Objective To explore the application value of probiotics combined with compound polyethylene glycol powder+lactulose in bowel preparation for colonoscopy in patients with chronic constipation(CC).Methods CC patients who were to undergo colonoscopy from June 2022 to December 2023 in the Department of Gastroenterology of Zhejiang Putuo Hospital were included.Using the randomized numerical table method,the patients were randomly divided into the probiotic group(probiotics combined with compound polyethylene glycol powder+lactulose)and the control group(compound polyethylene glycol powder+lactulose).Bowel cleanliness[Boston Bowel Preparedness Scale(BBPS)score and bowel cleanliness efficiency],intestinal bubble score,colonoscopy quality indicators(polyp detection rate,adenoma detection rate,colonoscopy operation time,and colonoscopy completion rate),tolerability(tolerance rate and re-examination acceptance rate),and the incidence of adverse reactions were assessed and compared between the probiotic group and the control group.Results A total of 120 CC patients,60 in each group,were included in the study,and the colonoscopy completion rate was 100.00%in both the probiotic and control groups.The left hemicolon score,middle colon score,right hemicolon score,BBPS score,bowel cleansing effective rate,and bowel bubble score satisfaction were significantly higher in the probiotic group than those in the control group(P<0.05);the difference between the polyp detection rate and adenoma detection rate of the two groups was not statistically significant(P>0.05).Compared with the control group,the colonoscopy operation time in the probiotic group was short,the tolerance rate and re-examination rate were high,and the incidence of adverse reactions was low(P<0.05).Conclusion Probiotics can improve the efficacy and safety of compound polyethylene glycol dispersions+lactulose in bowel preparation for colonoscopy in CC patients.

关 键 词：益生菌 复方聚乙二醇散 乳果糖 慢性便秘 肠道准备 

分 类 号：R574.62[医药卫生—消化系统]