1例蜡样芽孢杆菌导致中枢神经系统感染的案例报告并文献复习  

Central nervous system infection caused by Bacillus cereus:a case report and literature review

作　　者：黄钰茹 刘浩 崔彦[3] 俞淼 HUANG Yuru;LIU Hao;CUI Yan;YU Miao(Department of Pharmacy,Dazu Hospital Affiliated of Chongqing Medical University,Chongqing 402360,China;Department of Pharmacy,the First Affiliated Hospital of Chongqing Medical University,Chongqing 400042,China;Department of Pharmacy,Chongqing Fifth People's Hospital,Chongqing 400062,China)

机构地区：[1]重庆医科大学附属大足医院药剂科,重庆402360 [2]重庆医科大学附属第一医院药学部,重庆400042 [3]重庆市第五人民医院药剂科,重庆400062

出　　处：《中国药师》2024年第3期536-544,共9页China Pharmacist

基　　金：重庆市南岸区科卫联合医学科研项目(2021-02)。

摘　　要：本文报告1例颅内肿瘤患者感染蜡样芽孢杆菌(Bacillus cereus)的诊疗过程,收集43例已报道的蜡样芽孢杆菌导致中枢神经系统(CNS)感染的案例,同时复习国内外相关文献,对蜡样芽孢杆菌导致CNS感染的临床表现、治疗方案等进行分析,为临床治疗蜡样芽孢杆菌导致的CNS感染提供借鉴。该类感染在血液恶性肿瘤、早产儿、颅内恶性肿瘤、中心粒细胞减少症的患者中较为多见,应尽早选用万古霉素、美罗培南等敏感且易透过CNS的抗菌药物进行治疗。蜡样芽孢杆菌在临床常被当作污染菌,近年来其导致的感染案例报道越来越多。在易感人群中应高度警惕,尽早开始经验治疗,以改善预后。The diagnosis and treatment process of a patient with intracranial tumor infected with Bacillus cereus was reported in this article,a total of 43 reported cases of central nervous system(CNS)infection caused by Bacillus cereus were collected,and the relevant literature at home and abroad was reviewed to analyze the clinical manifestations and treatment regimens of CNS infection caused by Bacillus cereus,providing references for clinical treatment of CNS infection caused by Bacillus cereus.This type of infection is more common in patients with hematologic malignancies,premature infants,intracranial malignancies,and central granulocytopenia,and sensitive and easily transmissible CNS antibiotics,such as vancomycin and meropenem should be selected for treatment as early as possible.Bacillus cereus is often regarded as a contaminating bacterium in clinical practice.However,in recent years,more and more cases of infection caused by Bacillus cereus have been reported.High vigilance should be emphasized in susceptible populations to start empirical treatment as early as possible to improve the prognosis.

关 键 词：蜡样芽孢杆菌 中枢神经系统 感染 抗感染治疗 案例报告 文献复习 

分 类 号：R739.41[医药卫生—肿瘤] R742.9[医药卫生—临床医学]