Rosmarinic acid improves tracheal smooth muscle responsiveness and lung pathological changes in ovalbumin-sensitized rats  

作　　者：Vahideh Abbasnia Mohsen Foadoddini Delaram Eslimi Esfahani Mohammad Reza Khazdair Shahrbanoo Oryan 

机构地区：[1]Department of Biology,Payame Noor University,Tehran,Iran [2]Cardiovascular Diseases Research Center,Birjand University of Medical Sciences,Birjand,Iran [3]Department of Animal Sciences,Faculty of Biological Sciences,Kharazmi University,Tehran,Iran

出　　处：《Asian Pacific Journal of Tropical Biomedicine》2024年第3期100-105,共6页亚太热带生物医学杂志（英文版）

摘　　要：Objective:To evaluate the effect of rosmarinic acid on tracheal smooth muscle responsiveness and lung pathological changes in ovalbumin-sensitized rats.Methods:Rats were randomly divided into six groups:the control group,the asthmatic group,and the asthmatic groups treated with dexamethasone(1 mg/kg;oral gavage)or three doses of rosmarinic acid(0.5,1,and 2 mg/kg;oral gavage).For induction of asthma,rats received intraperitoneal injections and inhalation of ovalbumin.After 21 days,bronchoalveolar lavage fluid and lung samples were collected for histopathological analyses.Moreover,total and differential white blood cell counts were determined.Results:The rosmarinic acid-treated group had significantly lower tracheal smooth muscle responses to methacholine than the asthmatic group.In addition,rosmarinic acid reduced white blood cell count and the percentages of eosinophils,monocytes,and neutrophils while increasing the percentage of lymphocytes.Ovalbumin-induced lung pathological changes were significantly improved by treatment with rosmarinic acid.Conclusions:Rosmarinic acid improves tracheal smooth muscle responsiveness and lung pathological changes in ovalbumin-sensitized rats.

关 键 词：Rosmarinic acid ASTHMA OVALBUMIN Tracheal responsiveness Inflammation White blood cell 

分 类 号：R285.5[医药卫生—中药学]