MiT家族易位性肾癌影像诊断与鉴别诊断  

Imaging Diagnosis and Differential Diagnosis of MiT Family Translocation Renal Cell Carcinoma

作　　者：赵娜 史彬 陈东 宋德梅 曹锋 高飞[1] 董江宁 ZHAO Na;SHI Bin;CHEN Dong(West District,the First Affiliated Hospital of University of Science and Technology of China,Imaging Department of Anhui Cancer Hospital,Hefei,Anhui Province 230031,P.R.China)

机构地区：[1]中国科学技术大学附属第一医院西区安徽省肿瘤医院影像科,合肥230031

出　　处：《临床放射学杂志》2024年第3期402-409,共8页Journal of Clinical Radiology

摘　　要：目的 探讨MiT家族易位性肾细胞癌(MiT RCC)的影像表现及与肾透明细胞癌(CCRCC)及乳头状肾细胞癌(PRCC)的鉴别诊断价值。方法 选择经手术病理证实的11例MiT RCC患者CT及MRI影像资料,分析患者的性别及年龄、病灶大小、形态、出血、假包膜、强化模式、生长方式以及对周围组织侵犯等影像学特征,并与11例CCRCC、11例PRCC的影像特点对照分析。结果 11例MiT RCC患者中男3例,女8例,年龄10~73岁,平均(33.18±17.41)岁。11例MiT RCC与11例CCRCC和11例PRCC 3组间分析结果显示:患者年龄、性别、肿块位置、有无假包膜、有无出血、发病年龄分布、强化程度组间差异具有统计学意义(P<0.05);肿块大小及形态、钙化、坏死囊变、强化模式、生长方式、对组织侵犯以及转移征象差异无统计学意义(P>0.05)。MiT RCC相比CCRCC、PRCC发病年龄更小,女性更多见,出血发生率更高,更易表现为肾髓内生长,假包膜MiT RCC及CCRCC发生率均较高,明显高于PRCC(P<0.05);强化程度CCRCC>MiT RCC>PRCC(P<0.01)。结论 MiT RCC的影像学表现有一定特征性,结合好发于30岁以下的儿童及年轻人、出现肾轮廓内肿块伴出血、钙化、假包膜、多发淋巴结及远处转移,有助于提高术前诊断率。Objective To investigate the imaging features of MiT family translocation renal cell carcinoma(MiT RCC)and its differential diagnostic value with renal clear cell carcinoma(CCRCC) and papillary renal cell carcinoma(PRCC).Methods CT and MRI images of 11 patients with MiT RCC confirmed by surgery and pathology were selected.The imaging characteristics of the patients,such as gender,age,size,morphology,hemorrhage,pseudocapsule,enhancement pattern,growth pattern and invasion of surrounding tissues were analyzed,and the imaging characteristics were compared with those of 11 CCRCC and 11 PRCC.Results Among the 11 patients with MiT RCC,there were 3 males and 8 females.The average age of the patients was(33.18±17.41) years.The results of analysis among 11 MiT RCC,11 CCRCC,and11 PRCC showed that there were statistically significant differences among the three groups in age,sex,tumor location,presence or absence of false capsule,presence or absence of hemorrhage,the age distribution of onset,and degree of enhancement(P <0.05).There was no significant difference in the size and shape,calcification,necrotic cystic change,enhancement mode,growth mode,invasion to tissues and metastasis signs of the tumor(P> 0.05).Compared with CCRCC and PRCC,MiT RCC has a younger age of onset,is more common in women,has a higher incidence of bleeding,and is more likely to show intrarenal growth.The incidence of pseudocapsule was higher in MiT RCC and CCRCC than that of PRCC(P <0.05).The enhancement degree was CCRCC> MiT RCC> PRCC(P <0.01).Conclusion The imaging manifestations of MIT RCC have certain characteristics.It is helpful to improve the preoperative diagnosis rate in combination with children and young people under the age of 30 years,and the presence of masses in the renal contour with hemorrhage,calcification,false capsule,multiple lymph nodes and distant metastasis.

关 键 词：MiT家族易位肾细胞癌 肾透明细胞癌 乳头状肾细胞癌 计算机体层摄影术 磁共振成像 

分 类 号：R737.11[医药卫生—肿瘤]