心血管领域的难点及细菌纳米纤维素的应用潜力  

Difficulties in the Cardiovascular Field and the Potential Application of Bacterial Nanocellulose

作　　者：王广飞 李格丽 洪枫[1,2,3] WANG Guangfei;LI Geli;HONG Feng(Research Group of Microbial Engineering and Medical Materials,School of Biological and Medical Engineering,Donghua University,Shanghai 201620,China;National Innovation Center for Advanced Functional Fibers,Suzhou 215000,China;Scientific Research Base of Bacterial Nanofiber Manufacturing and Composite Technology,Chinese Society of Textile Engineering,Shanghai 201620,China)

机构地区：[1]东华大学生物与医学工程学院微生物工程与医学材料研究组,上海201620 [2]国家先进功能纤维创新中心,江苏苏州215000 [3]细菌纳米纤维制造及复合技术科研基地,中国纺织工程学会,上海201620

出　　处：《纤维素科学与技术》2024年第1期49-57,I0001,共10页Journal of Cellulose Science and Technology

基　　金：国家重点研发计划课题(2023YFB3810102)。

摘　　要：心血管疾病(心肌梗死、冠状动脉粥样硬化、高血压等)已成为全球人类死亡的主要原因,这些疾病目前主要依靠药物治疗,严重时需心脏冠脉搭桥等外科手术治疗。文中简述了小口径人工血管及人工心脏瓣膜需求的急迫性以及细菌纳米纤维素(BNC)的特点,回顾了BNC在心血管领域的最新研究进展并预测了今后的发展方向。细菌纳米纤维素因其形状可塑性、具有类细胞外基质的3D纤维网络结构、高持水性、血液和细胞相容性好等优点,在心血管领域中的应用潜力非常突出,为其今后在该领域中的发展奠定了基础。Cardiovascular diseases(myocardial infarction,coronary atherosclerosis,hypertension,etc.)have become the leading cause of human mortality worldwide,and these diseases are currently treated mainly with medications,and in severe cases,surgical procedures such as coronary artery bypass grafting are required.This paper briefly describes the urgent need for small-caliber artificial blood vessels and artificial heart valves as well as the characteristics of bacterial nanocellulose(BNC),reviews the recent research progress of BNC in the cardiovascular field,and predicts the future direction of development.Bacterial nanocellulose has outstanding potential for cardiovascular applications due to its shape plasticity,3D fiber network structure with extracellular matrix-like structure,high water-holding property,and good blood and cell compatibility,which lays the foundation for its future development in this field.

关 键 词：心血管疾病 人工血管 人工心脏瓣膜 细菌纳米纤维素 

分 类 号：R-1[医药卫生]