Basic Research Advances in China on Embryo Implantation,Placentation,and Parturition  

作　　者：Haili Bao Haibin Wang 

机构地区：[1]Fujian Provincial Key Laboratory of Reproductive Health Research,Department of Obstetrics and Gynecology,The First Affiliated Hospital of Xiamen University,School of Medicine,Xiamen University,Xiamen 361102,China [2]State Key Laboratory of Vaccines for Infectious Diseases,Xiang An Biomedicine Laboratory,School of Medicine,Xiamen University,Xiamen 361102,China

出　　处：《Maternal-Fetal Medicine》2024年第1期37-49,共13页母胎医学杂志（英文）

基　　金：supported by the National Key R&D Program of China (2022YFC2702500 and 2021YFC2700302);National Natural Science Foundation of China (82288102).

摘　　要：This review aimed to summarize the major progress in maternal-fetal medicine achieved by Chinese scientists in recent years.PubMed was systematically searched from January 2020 to November 2023.Publications that reported the progress in embryo implantation,placentation,and parturition made by Chinese scientists in the last 3 years were selected.The milestone events during gestation,embryo implantation,endometrial decidualization,placentation,and parturition are pivotal to a successful pregnancy.Embryo implantation requires intricate interactions between implantation-competent blastocysts and receptive endometrium.To adapt to pregnancy,endometrial stromal cells transform into specialized decidual cells,which occur spontaneously under the influence of ovarian hormones in humans but require the presence of embryos in mice.With embryonic development,the placenta forms to support fetal growth until parturition.The maternal-fetal interface is composed of diverse cell types,including endometrial decidual cells,placental trophoblast cells,endothelial cells,and various immune cells,a sophisticated interplay among which contributes to the maintenance of pregnancy.Near term,the uterus transitions from quiescence to contractility,in preparation for delivery.Disruptions to these events lead to pregnancy-related disorders such as repeated implantation failure,recurrent pregnancy loss,preeclampsia,fetal growth restriction,preterm birth,and infertility.In recent years,Chinese scientists have made prominent achievements in basic research on the aforementioned pregnancy events.Chinese scientists have made remarkable contributions to reproductive biology and maternal-fetal medicine research in recent years,highlighting future research directions in this field.

关 键 词：Embryo implantation DECIDUALIZATION PLACENTATION Maternal-fetal interface PARTURITION 

分 类 号：R714.1[医药卫生—妇产科学]