利那洛肽联合复方聚乙二醇用于肠道准备的安全性及有效性  

Safety and efficacy of linaclotide combined with polyethylene glycol for bowel preparation

作　　者：李欣蕾 陈曦[1] 张海燕[1] 姜娜[1] 张珊[1] 慈向男 刘希双[1] LI Xinlei;CHEN Xi;ZHANG Haiyan;JIANG Na;ZHANG Shan;CI Xiangnan;LIU Xishuang(Department of Gastroenterology,the Affiliated Hospital of Qingdao University,Qingdao 266700,China)

机构地区：[1]青岛大学附属医院消化内科,山东青岛266700

出　　处：《基础医学与临床》2024年第4期518-522,共5页Basic and Clinical Medicine

摘　　要：目的 研究利那洛肽联合复方聚乙二醇(PEG)用于结肠镜前肠道准备的安全性和有效性。方法 选取2023年1月至6月于青岛大学附属医院消化内科行结肠镜检查的612例患者。采用随机数字表法将其分为1组(1 L PEG+2 L PEG组)、2组(利那洛肽+2 L PEG组)和3组(1 L PEG+利那洛肽+1 L PEG组),每组各204例。比较各组渥太华评分(OBPS)、进镜时间、首次排便时间、排便次数、患者不良反应发生率和患者耐受性。结果 共601名患者按要求完成肠道准备及结肠镜检查。1组和2组OBPS和进镜时间差异无统计学意义。2组首次排便时间短于1组和3组(P<0.05)。1组排便次数多于2组和3组(P<0.05)。2组和3组不良反应发生率显著低于1组(P<0.05)。患者整体耐受性评分1组低于2组和3组(P<0.05)。结论 2 L PEG联合290μg利那洛肽用于结肠镜前肠道准备的效果与3 L PEG相似,且不良反应发生率低,患者耐受性好;对于1次性服用大剂量PEG不耐受的患者可考虑应用1 L PEG+利那洛肽+1 L PEG方案。Objective To evaluate safety and efficacy of linaclotide combined with polyethylene glycol(PEG)for bowel preparation.Methods A total of 612 patients from Department of Gastroenterology at the Affiliated Hospital of Qingdao University for colonoscopy examination from January to June 2023 were selected.They were divided into group 1(1 L PEG+2 L PEG),group 2(linaclotide+2 L PEG)and group 3(1 L PEG+linaclotide+1 L PEG)by random number table method,with 204 cases in each group.The Ottawa Bowel Preparation Quality Scale(OBPS),the insertion time of colonoscopy,the time of the first defecation,the frequency of defecations,the occurrence of adverse effects and patients′tolerability were compared among the three groups.Results A total of 601 patients completed bowel preparation and accepted colonoscopy.Group 1 exhibited no statistically significant differences to group 2 with regards to OBPS and insertion time.However,Group 2 demonstrated a shorter duration for the time of the first defecation in comparison to both group 1 and group 3(P<0.05).Group 1 displayed a higher frequency of defecations as compared to Group 2 and Group 3(P<0.05).The incidence of adverse reactions was significantly lower in group 2 and group 3 than in group 1(P<0.05).The overall tolerance score of patients in group 1 was lower than that in group 2 and group 3(P<0.05).Conclusions The effect of combining 2 L PEG with 290μg of linaclotide for bowel preparation before colonoscopy is similar to that of 3 L PEG.It can reduce the incidence of adverse reactions and patients exhibit good tolerance.For patients who are intolerant to a single high-dose administration of PEG,they need divided-dose regimen of 2 L PEG in combination with linaclotide.

关 键 词：利那洛肽 肠道准备 聚乙二醇 结肠镜 

分 类 号：R574.6[医药卫生—消化系统]