吡嘧司特钾联合普拉洛芬治疗过敏性结膜炎的临床效果  

Clinical efficacy of pyrimidolast potassium combined with praprofen in the treatment of allergic conjunctivitis

作　　者：温晓鸥 WEN Xiaoou(Department of Ophthalmology,Beijing Gulou Hospital of Traditional Chinese Medicine,Beijing 100009,China)

机构地区：[1]北京市鼓楼中医医院眼科,北京100009

出　　处：《基础医学与临床》2024年第4期539-543,共5页Basic and Clinical Medicine

摘　　要：目的 探讨吡嘧司特钾联合普拉洛芬滴眼液治疗过敏性结膜炎(AC)的临床效果。方法 选择2021年3月至2023年3月,北京市鼓楼中医医院就诊的186例AC患者。随机分为观察组与对照组。每组各93例。两组均使用吡嘧司特钾滴眼液,1~2滴/次,bid,观察组患者加用普拉洛芬滴眼液,1~2滴/次,qid,两组患者使用药物时间均为14 d。比较两组临床症状、体征积分、泪膜稳定性及角膜上皮损伤情况。结果 治疗后,观察组总有效率93.54%高于对照组80.65%。观察组和对照组的症状分数分别为0.19±0.66和0.70±0.69。体征积分分别为0.09±0.51和0.42±0.40。泪膜稳定性分别为10.81±2.58和9.39±1.87。角膜上皮损伤情况分别为0.98±0.46和2.05±0.90差异有统计学意义(P<0.05)。结论 相对于仅使用吡嘧司特钾滴眼液治疗过敏性结膜炎患者,联合应用普拉洛芬滴眼液可以协同增强药物疗效,更好地改善患者的不适症状和体征,能有效修复角膜损伤,稳定泪膜。Objective To investigate the clinical effect of pyrimidolast potassium combined with praprofen eye drops in the treatment of allergic conjunctivitis(AC).Methods From March 2021 to March 2023,186 patients with AC were selected from Beijing Gulou Hospital of Traditional Chinese Medicine.The patients were randomly assigned to a observation group and a control group with 93 in each.Pyrimidolast potassium eye drops(1-2 drops,b.i.d,)was given to both groups,and praprofen eye drops(1-2 drops,q.i.d)was given only to the observation group.Both groups of patients were treated for 14 days.Clinical symptoms,signs scores,tear film stability and corneal epithelium injury were compared between the two groups.Results After treatment,the total effective rate of observation group(93.54%)was higher than that of control group(80.65%).Symptom scores in observation group and control group were 0.19±0.66 and 0.70±0.69,respectively.The scores of physical signs were 0.09±0.51 and 0.42±0.40,respectively.Tear film stability was 10.81±2.58 and 9.39±1.87,respectively.The injury of corneal epithelium was 0.98±0.46 and 2.05±0.90,respectively,and the difference was statistically significant(P<0.05).Conclusions Compared with the patients treated with pyriferast potassium eye drops only,the combined application of pralprofen eye drops can synergically enhance the efficacy of drugs,improve the symptoms and signs of patients,effectively repair corneal injury and stabilize tear film.

关 键 词：过敏性结膜炎 吡嘧司特钾 普拉洛芬 滴眼液 

分 类 号：R777[医药卫生—眼科]