Surface roughness and its role in mediating cell adhesion on cobalt-chromium-molybdenum alloys  

作　　者：Satoshi Migita 

机构地区：[1]Graduate School of Science and Engineering,Yamagata University,Yonezawa,Japan

出　　处：《Biosurface and Biotribology》2023年第4期161-168,共8页生物表面与生物摩擦学（英文）

基　　金：Japan Society for the Promotion of Science,Grant/Award Number:JP19K12798。

摘　　要：Co-Cr-Mo ally(CCM)is commonly used for orthopaedic and dental implants due to its excellent mechanical properties and corrosion resistance.However,the influence of surface roughness on cell attachment and proliferation remains unclear.This study aimed to elucidate the impact of surface roughness of CCM on the attachment and proliferation of osteoblasts.CCM samples with different values of surface rouges were prepared by polishing.MC3T3-E1 mouse osteoblasts were used for cell culture experiments.Cell attachment,morphology,and the expression of actin stress fibres,vinculin,and distri-bution of yes-associated protein were analysed.Our results suggest that surface rough-ness does not significantly affect cell attachment and proliferation on CCM,unlike on titanium.Thus implies that other properties of CCM,such as physicochemical properties,may play a more substantial role in modulating cell behaviour.This study provides important insights into the design of CCM implants,suggesting that approaches beyond tuning surface roughness may be necessary to improve biocompatibility and osseointegration.

关 键 词：BIOINTERFACE biological reaction biological response BIOMATERIALS biomedical application biosurface 

分 类 号：TG144[一般工业技术—材料科学与工程]