Genetic Insights into Glycine’s Protective Role Against CAD—European and East Asia,2015 and 2020  

作　　者：Jiaying Yu Zhuolin Zhu Ting Wang Yuanhao Wei Lianjie Huang Qianru Zhang Yuting Zhang Yiran Wang Guiyou Liu Xiang Shu Rennan Feng 

机构地区：[1]Department of Nutrition and Food Hygiene,School of Public Health,Harbin Medical University,Harbin City,Heilongjiang Province,China [2]Key Laboratory of Precision Nutrition and Health of Ministry of Education,School of Public Health,Harbin Medical University,Harbin City,Heilongjiang Province,China [3]Songyang County Center for Disease Prevention and Control,Songyang City,Zhejiang Province China [4]Department of Neurology,Xuanwu Hospital,Capital Medical University,Beijing,China [5]Department of Epidemiology and Biostatistics,Memorial Sloan Kettering Cancer Center,New York City,NY,USA

出　　处：《China CDC weekly》2024年第9期168-172,I0003-I0008,共11页中国疾病预防控制中心周报（英文）

基　　金：Supported by the National Natural Science Foundation of China(82273612),and by Open Project of Key Laboratory of Science and Engineering for the Multi-Modal Prevention and Control of Major Chronic Diseases,Ministry of Industry and Information Technology(Grant No.MCD-2023-1-09).

摘　　要：Introduction:The purpose of this study is to examine the potential causal relationship between levels of circulating glycine and coronary artery disease(CAD)using a two-step Mendelian randomization(MR)analysis.Methods:We analyzed data from genome-wide association studies(GWAS)conducted on European and East Asian populations.To assess the causal effects of circulating glycine levels on the risk of CAD.We used the inverse-variance weighting(IVW),weighted median(WM),MR-Egger,and Mendelian Randomization Pleiotropy RESidual Sum and Outlier(MR-PRESSO)methods.Furthermore,we conducted mediation analysis to investigate the contribution of blood pressure and other cardiovascular disease-related traits.Results:The two-step Mendelian randomization analysis revealed that higher levels of glycine in the blood were associated with a reduced risk of CAD in Europeans[odds ratio(OR)=0.84,95%confidence interval(CI):0.72,−0.98;P=0.029]and East Asians:(OR=0.76,95%CI:0.66,−0.89;P=3.57×10−4).Sensitivity analysis confirmed the robustness of these findings.Additionally,our results suggest that about 6.06%of the observed causal effect is mediated through genetically predicted systolic blood pressure(SBP)in the European population.Discussion:Our results contribute to the current knowledge regarding the involvement of glycine in the progression of CAD,and provide valuable methodological insights for the prevention and treatment of this condition.

关 键 词：CAD prevention INVOLVEMENT 

分 类 号：R543.3[医药卫生—心血管疾病] R96[医药卫生—内科学]