脂联素在眼底新生血管性疾病中的作用  

Role of adiponectin in fundus neovascularization disease

作　　者：张小丹(综述) 颜华(审校)[1] Zhang Xiaodan;Yan Hua(Department of Ophthalmology,Tianjin Medical University General Hospital,Ministry of Education International Joint Laboratory of Ocular Diseases,Tianjin Key Laboratory of Ocular Trauma,Tianjin Institute of Eye Health and Eye Diseases,China-UK“Belt and Road”Ophthalmology Joint Laboratory,Tianjin 300052,China)

机构地区：[1]天津医科大学总医院眼科、教育部眼部疾病研究国际合作联合实验室、天津市眼外伤研究与转化重点实验室、天津市眼健康与眼疾病研究所、天津市“一带一路”中外联合研究中心,天津300052

出　　处：《中华实验眼科杂志》2024年第3期301-304,共4页Chinese Journal Of Experimental Ophthalmology

摘　　要：眼底新生血管性疾病是脉络膜和视网膜病理性血管生长引起的一系列临床病理改变,是一类严重影响视力的眼底病变,目前认为其主要发病原因是新生血管生成促进因子和抑制因子之间失衡。目前广泛使用的抗血管内皮生长因子的药物对许多眼底新生血管性疾病患者仍然无效。脂联素是由脂肪细胞分泌的一种内源性生物活性蛋白,具有增加胰岛素敏感性、调节糖和脂质代谢、抗炎、抑制新生血管形成等作用。脂联素及其受体在眼底新生血管性疾病中扮演了重要角色。目前尚不清楚脂联素在眼内是血管生成分子还是抗血管生成分子。了解脂联素及其受体在眼底新生血管性疾病的相关研究,有望为眼底新生血管性疾病的预防与治疗提供潜在治疗靶点和新的思路。本文对脂联素及其受体在眼底新生血管疾病的作用进行综述。Fundus neovascularization disease is a series of clinicopathological changes caused by pathological vascular growth of choroid and retina.It is a kind of fundus disease that seriously affects vision.At present,it is believed that the main cause of the disease is the imbalance between the promoters and inhibitors of angiogenesis.Currently widely used drugs against vascular endothelial growth factor(VEGF)are still ineffective in many patients with fundus neovascularization.Adiponectin(APN)is an endogenous bioactive protein secreted by adipocytes,which has the functions of increasing insulin sensitivity,regulating sugar and lipid metabolism,anti-inflammatory,and inhibiting neovascularization.In recent years,it has been found that APN and its receptors play an important role in fundus neovascularization diseases.Many studies have demonstrated the clinical predictive value of APN gene polymorphism in fundus neovascularization diseases.In vivo and in vitro models have verified the important proportion of APN in the pathological mechanism of chronic inflammation and neovascularization.The mechanism may be that APN inhibits VEGF-stimulated endothelial cell migration,and maintains normal vascular endothelial cell function.At this point we do not know whether APN is pro or anti angiogenic molecule in eye.Understanding the role of APN and its receptors in fundus neovascularization diseases is expected to provide potential therapeutic targets and new ideas for the prevention and treatment of fundus neovascularization diseases.This article reviews the role of APN and its receptor in fundus retinal neovascularization disease.

关 键 词：脂联素 新生血管 眼底疾病 综述 

分 类 号：R77[医药卫生—眼科]