原发纵隔CD20阴性弥漫大B细胞淋巴瘤1例并文献复习  

Primary mediastinal CD20-negative diffuse large B-cell lymphoma:a case report and literature review

作　　者：何海涛 王启 赵婕 张海溪[1,2,3] 高小丽 姚翔媚 HE Haitao;WANG Qi;ZHAO Jie;ZHANG Haixi;GAO Xiaoli;YAO Xiangmei(Department of Hematology,the First People′s Hospital of Yunnan Province,Kunming,Yunnan 650032,China;Department of Hematology,The Affiliated Hospital of Kunming University of Science and Technology,Kunming,Yunnan 650032,China;Yunnan Provincial Clinical Research Center for Hematologic Disease,Kunming,Yunnan 650032,China)

机构地区：[1]云南省第一人民医院血液科,云南昆明650032 [2]昆明理工大学附属医院血液科,云南昆明650032 [3]云南省血液系统疾病临床医学研究中心,云南昆明650032

出　　处：《现代医药卫生》2024年第7期1159-1161,1166,共4页Journal of Modern Medicine & Health

基　　金：云南省血液疾病临床医学中心项目(2021LCZXXF-XY03)。

摘　　要：回顾性分析1例原发纵隔CD20阴性弥漫大B细胞淋巴瘤病例的临床资料,并复习相关文献。患者,男,26岁反复胸痛3个月,影像学检查提示纵隔巨大占位,于外科行纵隔占位活检,术后免疫组织化学提示:CD20(-)、CD19(+)、PAX-5(+)、CD3(-)、CD5(-)、CD10(-)、TdT(-)、MUM1(+)、CD30(个别+)、Ki-67(约60%+)、BCL-2(+)、C-MYC(10%~20%)。诊断为CD20阴性弥漫大B细胞淋巴瘤,予以多疗程联合化疗后,疗效欠佳,病情进展,失访。CD20阴性弥漫大B细胞淋巴瘤侵袭性强,诊治难度大,预后差。The clinical data of one case of primary mediastinal CD20-negative diffuse large B-cell lymphoma were retrospectively analyzed,and the related literatures were reviewed.One 26-year-old male patient presented with recurrent chest pain for 3 months.Imaging examination showed a large space-occupying lesion in the mediastinum.Postoperative pathological immunohistochemistry showed CD20(-),CD19(+),PAX-5(+),CD3(-),CD5(-),CD10(-),TdT(-),MUM1(+),CD30(individual+),Ki-67(about 60%+),BCL-2(+),C-MYC(10%-20%).After multiple courses of combined chemotherapy,the efficacy was poor,the disease progressed,and he was lost to follow-up.Therefore,CD20-negative diffuse large B-cell lymphoma is highly invasive,difficult to diagnose and treat,and has a poor prognosis.

关 键 词：弥漫大B细胞淋巴瘤 CD20阴性 纵隔淋巴瘤 文献复习 

分 类 号：R733.4[医药卫生—肿瘤]