Intelligent nanomaterials for cancer therapy:recent progresses and future possibilities  

作　　者：Jing Wang Yuliang Zhao Guangjun Nie 

机构地区：[1]CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety,CAS Center of Excellence in Nanoscience,National Center for Nanoscience and Technology,Beijing,China [2]Center of Materials Science and Optoelectronics Engineering,University of Chinese Academy of Sciences,Beijing,China [3]CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety,CAS Center of Excellence in Nanoscience,National Center for Nanoscience and Technology,Beijing 100190,China [4]GBA Research Innovation Institute for Nanotechnology,Guangzhou 510700,Guangdong Province,China [5]Center of Materials Science and Optoelectronics Engineering,University of Chinese Academy of Sciences,Beijing 100049,China

出　　处：《Medical Review》2023年第4期321-342,共22页医学评论（英文）

基　　金：supported by the National Basic Research Plan of China(2018YFE0205300);the National Basic Science Center Project(T2288102);the Key Area Research and Development Program of Guangdong Province(2020B0101020004).

摘　　要：Intelligent nanomedicine is currently one of the most active frontiers in cancer therapy development.Empowered by the recent progresses of nanobiotechnology,a new generation of multifunctional nanotherapeutics and imaging platforms has remarkably improved our capability to cope with the highly heterogeneous and complicated na-ture of cancer.With rationally designed multifunctionality and programmable assembly of functional subunits,the in vivo behaviors of intelligent nanosystems have become increasingly tunable,making them more efficient in performing sophisticated actions in physiological and path-ological microenvironments.In recent years,intelligent nanomaterial-based theranostic platforms have showed great potential in tumor-targeted delivery,biological barrier circumvention,multi-responsive tumor sensing and drug release,as well as convergence with precise medication approaches such as personalized tumor vaccines.On the other hand,the increasing system complexity of anti-cancer nanomedicines also pose significant challenges in charac-terization,monitoring and clinical use,requesting a more comprehensive and dynamic understanding of nano-bio interactions.This review aims to briefly summarize the recent progresses achieved by intelligent nanomaterials in tumor-targeted drug delivery,tumor immunotherapy and temporospatially specific tumor imaging,as well as impor-tant advances of our knowledge on their interaction with biological systems.In the perspective of clinical translation,we have further discussed the major possibilities provided by disease-oriented development of anti-cancer nano-materials,highlighting the critical importance clinically-oriented system design.

关 键 词：intelligent nanomedicine anti-cancer nano-materials tumor microenvironment tumor vaccines immunotherapy personalized medication 

分 类 号：TB383[一般工业技术—材料科学与工程] R73[医药卫生—肿瘤]